The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review.
The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review.
复制标题
DOI：
10.3389/fphar.2020.565700
复制
发表时间：
2020
影响因子：
5.6
通讯作者：
Ortega MM
中科院分区：
文献类型：
--
作者：
Silva Dos Santos J;Gonçalves Cirino JP;de Oliveira Carvalho P;Ortega MM
山奈酚(KPF)是一种存在于水果和蔬菜中的黄酮类抗氧化剂。许多研究已经描述了膳食KPF在降低慢性病，特别是癌症风险方面的有益效果。然而，对中枢神经系统(CNS)中KPF作用的细胞和分子机制知之甚少。此外，KPF的结构性质和它们的糖基化以及这些化合物的生物益处之间的关系尚不清楚。这项研究的目的是回顾PubMed数据库在过去10年(2010-2020年)发表的研究，仅考虑涉及KPF(C15H10O6)及其衍生物在阿尔茨海默病、帕金森、缺血性中风、癫痫、严重抑郁障碍、焦虑症、神经病理性疼痛和胶质母细胞瘤等神经系统疾病中的孤立细胞效应的实验文章。本综述收录了27篇文献，介绍了KPF对神经系统影响的最新进展。KPF通过调节核因子-kB(NF-kB)、p38丝裂原活化蛋白激酶(P38MAPK)、丝氨酸/苏氨酸激酶(AKT)和β-连环蛋白级联等多种致炎信号通路，发挥多潜能的神经保护作用。此外，KPF苷元及其苷类化合物具有不同的生物利用度和药代动力学行为。通过抑制基质金属蛋白酶2、基质金属蛋白酶3和基质金属蛋白酶9，抑制活性氧的生成，调节超氧化物歧化酶和谷胱甘肽等内源性抗氧化剂，抑制β-淀粉样蛋白(β-A)的形成和聚集，以及通过调节脑源性神经营养因子发挥脑保护作用，对神经可塑性起重要作用。综上所述，我们认为KPF及其糖基化衍生物(KPF-3-O-鼠李糖苷、KPF-3-O-葡萄糖苷、KPF-7-O-芦丁糖苷和KPF-4‘-甲醚)在中枢神经系统疾病中具有多潜能的神经保护作用，进一步的研究可能会使KPF在这些疾病中的作用机制更加清晰。未来的体内研究还需要阐明KPF在中枢神经系统疾病中的作用机制以及糖基化对KPF生物活性的影响。
Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases, especially cancer. Nevertheless, little is known about the cellular and molecular mechanisms underlying KPF actions in the central nervous system (CNS). Also, the relationship between KPF structural properties and their glycosylation and the biological benefits of these compounds is unclear. The aim of this study was to review studies published in the PubMed database during the last 10 years (2010–2020), considering only experimental articles that addressed the isolated cell effect of KPF (C15H10O6) and its derivatives in neurological diseases such as Alzheimer's disease, Parkinson, ischemia stroke, epilepsy, major depressive disorder, anxiety disorders, neuropathic pain, and glioblastoma. 27 publications were included in the present review, which presented recent advances in the effects of KPF on the nervous system. KPF has presented a multipotential neuroprotective action through the modulation of several proinflammatory signaling pathways such as the nuclear factor kappa B (NF-kB), p38 mitogen-activated protein kinases (p38MAPK), serine/threonine kinase (AKT), and β-catenin cascade. In addition, there are different biological benefits and pharmacokinetic behaviors between KPF aglycone and its glycosides. The antioxidant nature of KPF was observed in all neurological diseases through MMP2, MMP3, and MMP9 metalloproteinase inhibition; reactive oxygen species generation inhibition; endogenous antioxidants modulation as superoxide dismutase and glutathione; formation and aggregation of beta-amyloid (β-A) protein inhibition; and brain protective action through the modulation of brain-derived neurotrophic factor (BDNF), important for neural plasticity. In conclusion, we suggest that KPF and some glycosylated derivatives (KPF-3-O-rhamnoside, KPF-3-O-glucoside, KPF-7-O-rutinoside, and KPF-4′-methyl ether) have a multipotential neuroprotective action in CNS diseases, and further studies may make the KPF effect mechanisms in those pathologies clearer. Future in vivo studies are needed to clarify the mechanism of KPF action in CNS diseases as well as the impact of glycosylation on KPF bioactivity.
登录
查看更多内容
影响因子：
4.2
作者：
Filomeni, Giuseppe;Graziani, Ilaria;Ciriolo, Maria R.
通讯作者：
Ciriolo, Maria R.
影响因子：
2.5
作者：
de Almeida, Reinaldo Nobrega;de Sousa, Damiao Pergentino;Mattei, Rita
通讯作者：
Mattei, Rita
影响因子：
6.7
作者：
Choi, Jae Sue;Islam, Md Nurul;Jung, Hyun Ah
通讯作者：
Jung, Hyun Ah
影响因子：
3.6
作者：
Gao, Wenqi;Wang, Wei;Deng, Zhifang
通讯作者：
Deng, Zhifang
影响因子：
5.6
作者：
Fisher, Robert S.;Acevedo, Carlos;Wiebe, Samuel
通讯作者：
Wiebe, Samuel