Modeling dilated cardiomyopathies in Drosophila.
Modeling dilated cardiomyopathies in Drosophila.
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DOI：
10.1016/j.tcm.2012.06.012
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发表时间：
2012-04
影响因子：
9.3
通讯作者：
Wolf MJ
中科院分区：
文献类型：
--
作者：
Wolf MJ
Over the past hundred years, the fruit fly, Drosophila melanogaster, has provided tremendous insights into genetics and human biology. Drosophila-based research utilizes powerful, genetically-tractable approaches to identify new genes and pathways that potentially contribute to human diseases. New resources available in the fly research community have advanced the ability to examine genome-wide effects on cardiac function and facilitate the identification of structural, contractile, and signaling molecules that contribute to cardiomyopathies. This powerful model system continues to provide discoveries of novel genes and signaling pathways that are conserved among species and translatable to human pathophysiology.
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