Increased discriminative stimulus potency of phencyclidine in C57B1/6 mice infected with the LP-BM5 retrovirus.
Increased discriminative stimulus potency of phencyclidine in C57B1/6 mice infected with the LP-BM5 retrovirus.
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增加了感染 LP-BM5 逆转录病毒的 C57B1/6 小鼠中苯环己哌啶的辨别刺激效力。
DOI：
10.1016/s0014-2999(98)00961-3
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发表时间：
1999
影响因子：
5
通讯作者：
Paul,IA
中科院分区：
文献类型：
--
作者：
English,JA;Bruce,KH;Paul,IA
Drug discrimination procedures in mice are used to study the neuropharmacology of a wide variety of drugs. In C57 Bl/6 mice, infection with the LP-BM5 murine leukemia virus leads to a syndrome (murine acquired immunodeficiency syndrome-MAIDS) characterized by immunocompromise, neurochemical alterations, and learning and memory deficits. Because the neurochemical and behavioral changes suggest that altered glutamatergic neurotransmission follows LP-BM5 infection, we studied the effects of infection on discriminative stimulus properties of phencyclidine (PCP), a Ca2+channel blocker at NMDA receptors. We also tested d-amphetamine and dizocilpine to assess the specificity of the discrimination. As expected, dizocilpine produced PCP-like responding. After animals were trained to discriminate PCP from saline, they were inoculated with LP-BM5 and the PCP dose-response functions repeatedly determined. The potency of PCP in this procedure was unchanged 3 weeks after infection, but was increased approximately fivefold 6 and 9 weeks after infection. Amphetamine 9 weeks after inoculation did not produce PCP-like responding, showing that the results were not caused by a loss of specificity of the discrimination. The time course for changes in PCP potency is similar to those of other behavioral and neurochemical changes reported after LP-BM5 infection. The results are consistent with an action of LP-BM5 infection at glutamatergic synapses.
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影响因子：
4.4
作者：
D. Klinman;H. Morse
通讯作者：
D. Klinman;H. Morse
鼠逆转录病毒引起的免疫缺陷综合征的中枢神经系统感染
影响因子：
3.3
作者：
Y. Sei;M. Makino;L. Vitković;S. Chattopadhyay;J. Hartley;P. K. Arora
通讯作者：
P. K. Arora
氟烷、1,1,1-三氯乙烷、亚硝酸异戊酯、氟草酯和奥沙西泮对小鼠的类似戊巴比妥的辨别刺激特性。
DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Rees,DC;Knisely,JS;Balster,RL;Jordan,S;Breen,TJ
通讯作者：
Breen,TJ
吸入甲苯对小鼠产生类似戊巴比妥的辨别刺激作用。
影响因子：
6.1
作者：
Rees,DC;Coggeshall,E;Balster,RL
通讯作者：
Balster,RL
小鼠中的戊巴比妥歧视。
DOI：
--
发表时间：
1987
期刊：
Alcohol and drug research
影响因子：
--
作者：
Balster,RL;Moser,VC
通讯作者：
Moser,VC