Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin.
Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin.
复制标题
多种神经肽刺激小细胞肺癌的克隆生长：缓激肽、加压素、胆囊收缩素、甘丙肽和神经降压素的作用。
作者：
Tariq Sethi;Enrique Rozengurt
我们测试了钙离子动员神经肽是否可以作为小细胞肺癌细胞的生长因子。神经肽缓激肽，神经降压素，胆囊收缩素和加压素在纳摩尔浓度刺激细胞内Ca2+浓度的快速和短暂的增加。重要的是，在相同浓度范围内的这些肽也引起应答性小细胞肺癌细胞系在半固体培养基中的集落形成的显著增加。在最佳浓度下，缓激肽、神经降压素、胆囊收缩素、血管加压素、甘丙肽和胃泌素释放肽在促进克隆生长方面同样有效。这些发现支持了小细胞肺癌的生长是由涉及多种神经肽的自分泌和旁分泌相互作用的广泛网络维持的假设。
We tested whether Ca(2+)-mobilizing neuropeptides can function as growth factors for small cell lung carcinoma cells. The neuropeptides bradykinin, neurotensin, cholecystokinin, and vasopressin at nanomolar concentrations stimulated a rapid and transient increase in the intracellular concentration of Ca2+. Crucially, these peptides in the same concentration range also caused a marked increase in colony formation in semisolid medium in responsive small cell lung carcinoma cell lines. At optimal concentrations bradykinin, neurotensin, cholecystokinin, vasopressin, galanin, and gastrin-releasing peptide were equally effective in promoting clonal growth. These findings support the hypothesis that small cell lung carcinoma growth is sustained by an extensive network of autocrine and paracrine interactions involving multiple neuropeptides.
影响因子：
11.2
作者：
E. Simms;A. Gazdar;P. Abrams;J. Minna
通讯作者：
E. Simms;A. Gazdar;P. Abrams;J. Minna
人类神经素作为小细胞肺癌的潜在肿瘤标志物：特异性放射免疫测定的应用。
DOI：
10.1210/jcem-51-4-892
发表时间：
1980
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
North,WG;Maurer,LH;Valtin,H;O'Donnell,JF
通讯作者：
O'Donnell,JF
β-内啡肽和神经降压素刺激人 SCLC 细胞的体外克隆生长。
影响因子：
5
作者：
Davis,TP;Burgess,HS;Crowell,S;Moody,TW;Culling-Berglund,A;Liu,RH
通讯作者：
Liu,RH