Pyroptosis, a new bridge to tumor immunity.
Pyroptosis, a new bridge to tumor immunity.
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上睑下垂，通往肿瘤免疫的新桥梁。
DOI：
10.1111/cas.15059
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发表时间：
2021-10
期刊：
影响因子：
5.7
通讯作者：
Bai Y
中科院分区：
文献类型：
--
作者：
Li L;Jiang M;Qi L;Wu Y;Song D;Gan J;Li Y;Bai Y
焦亡是指气皮蛋白（GSDM）介导的程序性细胞死亡（PCD）过程。我们对焦亡的理解已经扩展到细胞之外，并且已知涉及细胞外反应。最近，由于其在激活免疫系统中的新作用，人们对焦亡的兴趣越来越大。与此同时，利用免疫反应杀死癌细胞的焦亡介导疗法也在临床环境中取得了显著的成功。在这篇综述中，我们讨论了由焦亡激活诱导的免疫反应是一把双刃剑，影响肿瘤发生的所有阶段。一方面，炎症小体介导的焦亡激活和焦亡产生的细胞因子的释放改变了免疫微环境，通过逃避免疫监视促进肿瘤的发展。另一方面，焦亡产生的细胞因子也可以收集免疫细胞并点燃免疫系统，以提高肿瘤免疫治疗的效率。焦亡也与一些免疫检查点有关，特别是程序性死亡‐1 （PD‐1）或程序性死亡‐配体1 （PD‐L1）。在这篇综述中，我们主要关注我们目前对免疫系统和肿瘤通过焦亡过程之间相互作用的理解，并讨论它们作为潜在治疗靶点的应用。由焦亡激活引起的免疫反应是一把双刃剑，影响肿瘤发生的所有阶段。一方面，炎症小体介导的焦亡激活和焦亡产生的细胞因子的释放改变了免疫微环境，通过逃避免疫监视促进肿瘤的发展。另一方面，焦亡产生的细胞因子也可以收集免疫细胞并点燃免疫系统，以提高肿瘤免疫治疗的效率。
Pyroptosis refers to the process of gasdermin (GSDM)‐mediated programmed cell death (PCD). Our understanding of pyroptosis has expanded beyond cells and is known to involve extracellular responses. Recently, there has been an increasing interest in pyroptosis due to its emerging role in activating the immune system. In the meantime, pyroptosis‐mediated therapies, which use the immune response to kill cancer cells, have also achieved notable success in a clinical setting. In this review, we discuss that the immune response induced by pyroptosis activation is a double‐edged sword that affects all stages of tumorigenesis. On the one hand, the activation of inflammasome‐mediated pyroptosis and the release of pyroptosis‐produced cytokines alter the immune microenvironment and promote the development of tumors by evading immune surveillance. On the other hand, pyroptosis‐produced cytokines can also collect immune cells and ignite the immune system to improve the efficiency of tumor immunotherapies. Pyroptosis is also related to some immune checkpoints, especially programmed death‐1 (PD‐1) or programmed death‐ ligand 1 (PD‐L1). In this review, we mainly focus on our current understanding of the interplay between the immune system and tumors that process through pyroptosis, and debate their use as potential therapeutic targets. The immune response induced by pyroptosis activation is a double‐edged sword that affects all stages of tumorigenesis. On the one hand, the activation of inflammasome‐mediated pyroptosis and the release of pyroptosis‐produced cytokines alter the immune microenvironment and promote the development of tumors by evading immune surveillance. On the other hand, pyroptosis‐produced cytokines can also collect immune cells and ignite the immune system to improve the efficiency of tumor immunotherapies.
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DOI：
10.1084/jem.20161707
发表时间：
2017-06-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Daley D;Mani VR;Mohan N;Akkad N;Pandian GSDB;Savadkar S;Lee KB;Torres-Hernandez A;Aykut B;Diskin B;Wang W;Farooq MS;Mahmud AI;Werba G;Morales EJ;Lall S;Wadowski BJ;Rubin AG;Berman ME;Narayanan R;Hundeyin M;Miller G
通讯作者：
Miller G
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
DOI：
10.2119/molmed.2014.00232
发表时间：
2014-12-16
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Dinarello, Charles Anthony
通讯作者：
Dinarello, Charles Anthony
影响因子：
3.8
作者：
Bollino, Dominique;Colunga, Aric;Aurelian, Laure
通讯作者：
Aurelian, Laure
影响因子：
28.2
作者：
Erkes, Dan A.;Cai, Weijia;Aplin, Andrew E.
通讯作者：
Aplin, Andrew E.