Heterogeneity in subjective cognitive decline in the Sino Longitudinal Study on Cognitive Decline(SILCODE): Empirically derived subtypes, structural and functional verification.
Heterogeneity in subjective cognitive decline in the Sino Longitudinal Study on Cognitive Decline(SILCODE): Empirically derived subtypes, structural and functional verification.
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DOI：
10.1111/cns.14327
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发表时间：
2023-12
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
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我们评估了主观认知衰退（SCD）亚型是否可以在中国认知衰退纵向研究（SILCODE） SCD队列中经验性衍生，并检查了相关的神经影像学标志物、生物标志物和临床结果。对124名SCD SILCODE参与者和57名正常对照（NC）受试者的8项神经心理测试成绩进行聚类分析。采用结构和功能神经影像学指标评价SCD亚组。出现了四种亚型：(1)执行障碍/混合型SCD (n = 23),(2)神经精神型SCD (n = 24),(3)健忘性SCD (n = 22),(4)在神经心理测试中表现正常的聚类衍生型正常（n = 55）。与NC组相比，每个亚组在灰质（GM）体积和低频波动（ALFF）幅度上表现出不同的模式。相对于NC，只有神经精神SCD组的分数各向异性（FA）值较低。经验衍生的SCD亚型的鉴定表明SCD神经心理学特征存在异质性。聚类衍生的正常组可能代表大多数没有表现出进行性认知衰退的SCD个体；执行障碍/混合性SCD和遗忘性SCD可能是进展性认知衰退的高危人群；最后，神经精神性SCD可能是SCD研究的一个新课题。我们利用基于八种神经心理学测量的聚类分析从SILCODE SCD队列中得出亚组，并检查了相对于NC的每个聚类衍生亚组的结构和功能指数模式。出现了四个SCD亚组：执行障碍/混合型、神经精神型、健忘症和集群衍生的正常组。
We evaluated whether Subjective Cognitive Decline (SCD) subtypes could be empirically derived within the Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes. A cluster analysis was performed on eight neuropsychological test scores from 124 SCD SILCODE participants and 57 normal control (NC) subjects. Structural and functional neuroimaging indices were used to evaluate the SCD subgroups. Four subtypes emerged: (1) dysexecutive/mixed SCD (n = 23), (2) neuropsychiatric SCD (n = 24), (3) amnestic SCD (n = 22), and (4) cluster‐derived normal (n = 55) who exhibited normal performance in neuropsychological tests. Compared with the NC group, each subgroup showed distinct patterns in gray matter (GM) volume and the amplitude of low‐frequency fluctuations (ALFF). Lower fractional anisotropy (FA) values were only found in the neuropsychiatric SCD group relative to NC. The identification of empirically derived SCD subtypes demonstrates the presence of heterogeneity in SCD neuropsychological profiles. The cluster‐derived normal group may represent the majority of SCD individuals who do not show progressive cognitive decline; the dysexecutive/mixed SCD and amnestic SCD might represent high‐risk groups with progressing cognitive decline; and finally, the neuropsychiatric SCD may represent a new topic in SCD research. We empirically derived subgroups from the SILCODE SCD cohort using cluster analysis based on eight neuropsychological measures and examined patterns of structural and functional indices of each cluster‐derived subgroup relative to NC. Four SCD subgroups emerged: dysexecutive/mixed, neuropsychiatric, amnestic, and a cluster‐derived normal group.
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