Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study.
Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study.
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DOI：
10.1111/ppe.12004
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发表时间：
2012-11
影响因子：
2.8
通讯作者：
Cooper WO
中科院分区：
文献类型：
--
作者：
Bobo WV;Davis RL;Toh S;Li DK;Andrade SE;Cheetham TC;Pawloski P;Dublin S;Pinheiro S;Hammad T;Scott PE;Epstein RA Jr;Arbogast PG;Morrow JA;Dudley JA;Lawrence JM;Avalos LA;Cooper WO
关于抗癫痫药物（AED）在妊娠期的使用程度知之甚少，特别是对于较新的药物。我们的目的是评估美国孕妇使用AED的情况是否有所增加，2001-2007.我们分析了2001年1月1日至2007年12月31日期间妊娠药物暴露风险评估计划（MEPREP）数据库的数据。我们确定了分娩时年龄在15-45岁之间的妇女中的活产分娩，她们是MEPREP健康计划的成员（N = 585，615次分娩）。妊娠期AED暴露，通过门诊药房配药文件确定。1993年以前，较老的AED可用于临床;其他药物被认为是较新的AED。有关社会人口和医疗/生殖因素的信息来自相关的出生证档案。根据ICD-9编码确定母亲诊断。在2001年（每1 000例分娩15.7例）至2007年（每1 000例分娩21.9例）期间，妊娠期间使用AED的流行率有所增加，主要是由于使用新型AED增加了五倍。13%的AED暴露分娩涉及两种或更多种AED的组合。精神疾病是最常见的诊断，其次是癫痫和疼痛障碍，在AED使用者中，无论AED类型、受孕年份或妊娠期如何。2001年至2007年期间，由于新型AED的使用增加了五倍，妊娠期间AED的使用增加了。近八分之一的AED暴露分娩涉及同时使用一种以上的AED。可能需要对新型AED的生殖安全性进行更多的调查。
Little is known about the extent of antiepileptic drug (AED) use in pregnancy, particularly for newer agents. Our objective was to assess whether AED use has increased among pregnant women in the U.S., 2001-2007. We analyzed data from the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) database, 1 January 2001 to 31 December 2007. We identified live-born deliveries among women, aged 15-45 years on delivery date, who were members of MEPREP health plans (N = 585,615 deliveries). Pregnancy exposure to AEDs, determined through outpatient pharmacy dispensing files. Older AEDs were available for clinical use before 1993; other agents were considered newer AEDs. Information on sociodemographic and medical/reproductive factors was obtained from linked birth certificate files. Maternal diagnoses were identified based on ICD-9 codes. Prevalence of AED use during pregnancy increased between 2001 (15.7 per 1,000 deliveries) and 2007 (21.9 per 1,000 deliveries), driven primarily by a five-fold increase in the use of newer AEDs. Thirteen percent of AED-exposed deliveries involved a combination of two or more AEDs. Psychiatric disorders were the most prevalent diagnoses, followed by epileptic and pain disorders, among AED users regardless of AED type, year of conception or gestational period. AED use during pregnancy increased between 2001 and 2007, driven by a five-fold increase in the use of newer AEDs. Nearly one in eight AED-exposed deliveries involved the concomitant use of more than one AED. Additional investigations of the reproductive safety of newer AEDs may be needed.
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影响因子：
5
作者：
PIPER, JM;MITCHEL, EF;TAYLOR, P
通讯作者：
TAYLOR, P
影响因子：
5
作者：
RAY, WA;GRIFFIN, MR
通讯作者：
GRIFFIN, MR
影响因子：
120.7
作者：
Molgaard-Nielsen, Ditte;Hviid, Anders
通讯作者：
Hviid, Anders
影响因子：
5.6
作者：
Battino, D.;Bonizzoni, E.;Vajda, F.
通讯作者：
Vajda, F.
影响因子：
2.6
作者：
Raebel, MA;Ellis, JL;Andrade, SE
通讯作者：
Andrade, SE