Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications
Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications
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纳米颗粒的植物制造作为抗癌新药
DOI：
10.3390/molecules24234246
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发表时间：
2019-11
期刊：
影响因子：
4.6
通讯作者：
Lau Andy T. Y.
中科院分区：
文献类型：
--
作者：
Wei Qi-Yao;He Kai-Ming;Chen Jin-Ling;Xu Yan-Ming;Lau Andy T. Y.
癌症是全球最主要的死亡原因之一，也是延长预期寿命的主要障碍。尽管手术切除、化疗、放疗等主要治疗方法已经大大降低了癌症的死亡率，但由于肿瘤的转移、一系列药物不良反应和耐药性，生存率仍然较低。尽管如此，值得一提的是，越来越多的研究表明植物化学物质具有抗癌作用，可以调节分子途径和细胞事件，包括细胞凋亡、细胞增殖、迁移和侵袭。然而，它们的药理潜力因其水溶性低、稳定性低、吸收差和代谢快而受到阻碍。在这种情况下，纳米技术的发展创造了新的配方，以最大限度地发挥植物化学物质在抗癌治疗中的潜在用途。纳米载体可以增强植物化学物质的溶解度和稳定性，延长其在血液中的半衰期，甚至实现定点递送。这篇综述总结了在癌症治疗中利用纳米粒子的进展。我们特别介绍了纳米颗粒与芹菜素、白藜芦醇、姜黄素、表没食子儿茶素-3-没食子酸酯、6-姜酚和槲皮素结合在癌症治疗中的几种应用。
Cancer is one of the foremost causes of death globally and also the major stumbling block of increasing life expectancy. Although the primary treatment of surgical resection, chemotherapy, and radiotherapy have greatly reduced the mortality of cancer, the survival rate is still low because of the metastasis of tumor, a range of adverse drug reactions, and drug resistance. For all this, it is relevant to mention that a growing amount of research has shown the anticarcinogenic effect of phytochemicals which can modulate the molecular pathways and cellular events include apoptosis, cell proliferation, migration, and invasion. However, their pharmacological potential is hindered by their low water solubility, low stability, poor absorption, and rapid metabolism. In this scenario, the development of nanotechnology has created novel formulations to maximize the potential use of phytochemicals in anticancer treatment. Nanocarriers can enhance the solubility and stability of phytochemicals, prolong their half-life in blood and even achieve site-targeting delivery. This review summarizes the advances in utilizing nanoparticles in cancer therapy. In particular, we introduce several applications of nanoparticles combined with apigenin, resveratrol, curcumin, epigallocatechin-3-gallate, 6-gingerol, and quercetin in cancer treatment.
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影响因子：
8
作者：
Charbgoo F;Ahmad MB;Darroudi M
通讯作者：
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影响因子：
4.9
作者：
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4.6
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影响因子：
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影响因子：
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作者：
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