Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: a sleep study in human subjects.
Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: a sleep study in human subjects.
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DOI：
10.1016/j.neuroimage.2012.07.015
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发表时间：
2012-11-15
期刊：
影响因子：
5.7
通讯作者：
Fantini, Sergio
中科院分区：
文献类型：
--
作者：
Pierro, Michele L.;Sassaroli, Angelo;Bergethon, Peter R.;Ehrenberg, Bruce L.;Fantini, Sergio
关键词：
在人类睡眠研究中，我们使用近红外光谱(NIRS)研究了大脑脱氧和氧合血红蛋白浓度([Hb]和[HBO])的自发低频振荡(LFO)的幅度和相位。幅度和相位分析基于解析信号法，并使用相量代数将测量的[HB]和[HBO]振荡分解为脑血容量(CBV)和血流速度(CBFV)振荡。我们发现[HB]与[HB]相比存在更大的相领先[HBO]非快速眼动睡眠期间的LFO相对于清醒和快速眼动睡眠状态([HB]相导联的最大增量：~π/2)。此外，在非REM睡眠期间，相对于唤醒和REM睡眠状态，[HB]和[HBO]LFO的幅度被抑制(最大幅度下降：87%)。相关的脑血容量和血流速度振荡在睡眠期间保持它们的相对相位差，而它们的幅度在非快速眼动睡眠中减弱。这些结果表明，NIRS测量的[HB]和[HBO]振荡的相位-幅度分析在研究与脑生理、激活和病理条件相关的血流动力学方面具有潜力。
We have investigated the amplitude and phase of spontaneous low-frequency oscillations (LFOs) of the cerebral deoxy- and oxy-hemoglobin concentrations ([Hb] and [HbO]) in a human sleep study using near-infrared spectroscopy (NIRS). Amplitude and phase analysis was based on the analytic signal method, and phasor algebra was used to decompose measured [Hb] and [HbO] oscillations into cerebral blood volume (CBV) and flow velocity (CBFV) oscillations. We have found a greater phase lead of [Hb] vs. [HbO] LFOs during non-REM sleep with respect to the awake and REM sleep states (maximum increase in [Hb] phase lead: ~π/2). Furthermore, during non-REM sleep, the amplitudes of [Hb] and [HbO] LFOs are suppressed with respect to the awake and REM sleep states (maximum amplitude decrease: 87%). The associated cerebral blood volume and flow velocity oscillations are found to maintain their relative phase difference during sleep, whereas their amplitudes are attenuated during non-REM sleep. These results show the potential of phase-amplitude analysis of [Hb] and [HbO] oscillations measured by NIRS in the investigation of hemodynamics associated with cerebral physiology, activation, and pathological conditions.
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DOI：
10.1016/s0921-884x(96)95054-7
发表时间：
1997-02-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Kuboyama, T;Hori, A;Ueda, S
通讯作者：
Ueda, S
影响因子：
4.8
作者：
Freeman, WJ;Burke, BC;Holmes, MD
通讯作者：
Holmes, MD
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
20.6
作者：
BOASHASH, B
通讯作者：
BOASHASH, B
影响因子：
8.3
作者：
GRUBB, RL;RAICHLE, ME;TERPOGOS.MM
通讯作者：
TERPOGOS.MM