The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis.
The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis.
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DOI：
10.3390/v4112902
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发表时间：
2012-11-07
期刊：
影响因子：
--
通讯作者：
Fielding BC
中科院分区：
文献类型：
--
作者：
McBride R;Fielding BC
一种由新型冠状病毒引起的呼吸道疾病，被称为严重急性呼吸综合征冠状病毒（SARS-CoV），于2002年底在中国首次报道。随后，这种病毒在人与人之间的有效传播最终影响了全球30多个国家，导致约10%的感染者死亡率。通过隔离受感染的个人，最终控制了病毒的传播，自2004年4月以来没有报告任何感染。然而，该病毒的自然宿主从未被确定，也不知道该病毒是否会再次出现，因此，对该病毒的研究仍在继续。SARS-CoV基因组长度约为30 kb，预计包含14个功能性开放阅读框（orf）。基因组编码与已知冠状病毒蛋白同源的蛋白质，如复制酶蛋白（orf1a和1b）和四种主要结构蛋白：核衣壳(N)、刺突(S)、膜(M)和包膜(E)。sars冠状病毒还编码八种独特的蛋白质，称为辅助蛋白，没有已知的同源物。本文将对SARS-CoV附属蛋白的现有知识进行综述，包括：(i)表达和加工；（ii）对细胞过程的影响；（三）功能研究。
A respiratory disease caused by a novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), was first reported in China in late 2002. The subsequent efficient human-to-human transmission of this virus eventually affected more than 30 countries worldwide, resulting in a mortality rate of ~10% of infected individuals. The spread of the virus was ultimately controlled by isolation of infected individuals and there has been no infections reported since April 2004. However, the natural reservoir of the virus was never identified and it is not known if this virus will re-emerge and, therefore, research on this virus continues. The SARS-CoV genome is about 30 kb in length and is predicted to contain 14 functional open reading frames (ORFs). The genome encodes for proteins that are homologous to known coronavirus proteins, such as the replicase proteins (ORFs 1a and 1b) and the four major structural proteins: nucleocapsid (N), spike (S), membrane (M) and envelope (E). SARS-CoV also encodes for eight unique proteins, called accessory proteins, with no known homologues. This review will summarize the current knowledge on SARS-CoV accessory proteins and will include: (i) expression and processing; (ii) the effects on cellular processes; and (iii) functional studies.
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DOI：
10.1038/modpathol.3800439
发表时间：
2005-11
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
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通讯作者：
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影响因子：
64.5
作者：
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影响因子：
5.4
作者：
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Baric, RS
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7.6
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Tan YJ
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13.5
作者：
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