Evaluation of upper airway collapsibility using real-time MRI.
Evaluation of upper airway collapsibility using real-time MRI.
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DOI：
10.1002/jmri.25133
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Nayak KS
中科院分区：
文献类型：
--
作者：
Wu Z;Chen W;Khoo MC;Davidson Ward SL;Nayak KS
开发并演示一种实时MRI方法来评估睡眠呼吸暂停患者的上呼吸道塌陷性。数据在临床3特斯拉扫描仪上获取，采用改进的黄金角度视图排序的径向CAIPIRIHNA序列，并使用并行成像和时间有限差分稀疏性约束压缩感知进行重建。使用分段气道区域和同步面罩压力来计算沿上气道四个轴向位置的气道顺应性和投影闭合压力Pclose。该技术在5名青少年阻塞性睡眠呼吸暂停（OSA）患者、3名成人OSA患者和4名健康志愿者中进行了验证。在实验过程中实时监测心率、血氧饱和度、面罩压和腹/胸运动，以确定睡眠/清醒状态。学生t检验显示，健康对照组和OSA患者的依从性和Pclose均有显著差异（P< 0.001）。结果还表明，狭窄的气道部位并不总是对应较高的溃散性。采用所提出的方法，可以计算依从性和Pclose，并使用清醒扫描30min总扫描时间来量化OSA患者的气道溃散性。
To develop and demonstrate a real-time MRI method for assessing upper airway collapsibility in sleep apnea. Data were acquired on a clinical 3 Tesla scanner using a radial CAIPIRIHNA sequence with modified golden angle view ordering and reconstructed using parallel imaging and compressed sensing with temporal finite difference sparsity constraint. Segmented airway areas together with synchronized facemask pressure were used to calculate airway compliance and projected closing pressure, Pclose, at four axial locations along the upper airway. This technique was demonstrated in five adolescent obstructive sleep apnea (OSA) patients, three adult OSA patients and four healthy volunteers. Heart rate, oxygen saturation, facemask pressure, and abdominal/chest movements were monitored in real-time during the experiments to determine sleep/wakefulness. Student’s t-tests showed that both compliance and Pclose were significantly different between healthy controls and OSA patients (P< 0.001). The results also suggested that a narrower airway site does not always correspond to higher collapsibility. With the proposed methods, both compliance and Pclose can be calculated and used to quantify airway collapsibility in OSA with an awake scan of 30min total scan room time.
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影响因子：
3.3
作者：
Feng, Li;Grimm, Robert;Block, Kai Tobias;Chandarana, Hersh;Kim, Sungheon;Xu, Jian;Axel, Leon;Sodickson, Daniel K.;Otazo, Ricardo
通讯作者：
Otazo, Ricardo
DOI：
10.1164/ajrccm.164.4.2101127
发表时间：
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影响因子：
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作者：
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作者：
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作者：
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影响因子：
3.3
作者：
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通讯作者：
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