Noninvasive central systolic blood pressure, not peripheral systolic blood pressure, independently predicts the progression of carotid intima-media thickness in a Chinese community-based population
Noninvasive central systolic blood pressure, not peripheral systolic blood pressure, independently predicts the progression of carotid intima-media thickness in a Chinese community-based population
复制标题
无创中心收缩压（而非外周收缩压）独立预测中国社区人群颈动脉内膜中层厚度的进展
作者：
Pengfei Sun;Ying Yang;Guanliang Cheng;F. Fan;L. Qi;Lan Gao;Xiaoning Han;J. Jia;Y. Huo;Yan Zhang
本研究旨在探讨中心收缩压（cSBP）和外周收缩压（pSBP）对颈动脉内膜中层厚度（cIMT）进展的预测价值。本研究纳入了来自动脉粥样硬化队列的953名中国受试者，这些受试者具有完整的信息，包括基线cSBP、问卷信息、生化检查、基线和随访颈动脉超声定量数据。采用多元线性回归模型（针对可能的协变量进行调整）研究cSBP和pSBP对cIMT变化率的预测值。所有参与者的平均年龄为（52.11 ± 4.74岁）。cSBP、pSBP、最大cIMT和平均cIMT的基线水平为（132.55 ± 18.18）mmHg，（130.76 ± 15.40）mmHg，（813.52 ± 118.49）µm，（681.11 ± 99.90）μm，高血压388例，占40.71%;糖尿病172例，占18.05%;血脂异常671例，占70.41%。随访2.3年后，最大和平均cIMT变化率分别为8.70（-0.49-19.43）%和2.59（-4.72-10.81）%。cSBP（而非pSBP）的每标准差增加与最大（cSBP，β 1.07，95%CI 0.18-1.96，p = 0.018; pSBP，β 0.48，95%CI −0.45-1.41，p = 0.315）和平均值（对于cSBP，β 0.84%，95%CI 0.10 - 1.58，p = 0.027;对于pSBP，β 0.59%，95%CI-0.18-1.37，p = 0.135）调整可能的协变量后的cIMT变化率。总之，cSBP（而非pSBP）与我们以社区为基础的中国人群中的cIMT进展独立相关。cSBP应考虑用于CVD一级预防。
This study aimed to investigate the predictive values of central systolic blood pressure (cSBP) and peripheral systolic blood pressure (pSBP) for the progression of carotid intima-media thickness (cIMT). A total of 953 Chinese participants from an atherosclerosis cohort with complete information, including baseline cSBP, questionnaire information, biochemical examination, baseline, and follow-up carotid ultrasonography quantitative data, were included in this study. A multilinear regression model, adjusted for possible covariates, was used to investigate the predictive values of cSBP and pSBP for rate of cIMT change. The average age of all participants was (52.11 ± 4.74 years). The baseline levels of cSBP, pSBP, max cIMT, and mean cIMT were (132.55 ± 18.18)mmHg, (130.76 ± 15.40)mmHg, (813.52 ± 118.49)µm and (681.11 ± 99.90)µm, respectively Those with hypertension, diabetes and dyslipidemia accounted for 40.71% (388), 18.05% (172), and 70.41% (671), respectively. After 2.3 years of follow-up, the average rates of max and mean cIMT change were 8.70 (−0.49–19.43)% and 2.59 (−4.72–10.81)%, respectively. Per standard deviation increase of cSBP, but not pSBP, was associated with increases of max (for cSBP, β 1.07, 95%CI 0.18–1.96, p = 0.018; for pSBP, β 0.48, 95%CI −0.45–1.41, p = 0.315) and mean (for cSBP, β 0.84%, 95%CI 0.10−1.58, p = 0.027; for pSBP, β 0.59%, 95%CI −0.18–1.37, p = 0.135) cIMT change rate after adjusting for possible covariates. In conclusion, cSBP, but not pSBP, is independently associated with cIMT progression in our community-based Chinese population. cSBP should be considered for the purpose of CVD primary prevention.
从长远来看，改善儿童血压具有保护作用。
影响因子：
37.8
作者：
Zachariah,JustinP
通讯作者：
Zachariah,JustinP
DOI：
10.4158/ep15672.gl
发表时间：
2015-04
期刊：
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
影响因子：
--
作者：
Handelsman Y;Bloomgarden ZT;Grunberger G;Umpierrez G;Zimmerman RS;Bailey TS;Blonde L;Bray GA;Cohen AJ;Dagogo-Jack S;Davidson JA;Einhorn D;Ganda OP;Garber AJ;Garvey WT;Henry RR;Hirsch IB;Horton ES;Hurley DL;Jellinger PS;Jovanovič L;Lebovitz HE;LeRoith D;Levy P;McGill JB;Mechanick JI;Mestman JH;Moghissi ES;Orzeck EA;Pessah-Pollack R;Rosenblit PD;Vinik AI;Wyne K;Zangeneh F
通讯作者：
Zangeneh F
影响因子：
3.2
作者：
DeLoach, Stephanie S.;Appel, Lawrence J.;Chen, Jing;Joffe, Marshall M.;Gadegbeku, Crystal A.;Mohler, Emile R., III;Parsa, Afshin;Perumal, Kalyani;Rafey, Mohammed A.;Steigerwalt, Susan P.;Teal, Valerie;Townsend, Raymond R.;Rosas, Sylvia E.
通讯作者：
Rosas, Sylvia E.