Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort.
Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort.
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DOI：
10.1038/ajh.2009.156
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发表时间：
2009-12
影响因子：
3.2
通讯作者：
Rosas, Sylvia E.
中科院分区：
文献类型：
--
作者：
DeLoach, Stephanie S.;Appel, Lawrence J.;Chen, Jing;Joffe, Marshall M.;Gadegbeku, Crystal A.;Mohler, Emile R., III;Parsa, Afshin;Perumal, Kalyani;Rafey, Mohammed A.;Steigerwalt, Susan P.;Teal, Valerie;Townsend, Raymond R.;Rosas, Sylvia E.
慢性肾脏病（CKD）患者患心血管疾病的风险不成比例。本研究旨在评估两种心血管风险的无创性测量方法之间的相关性，脉搏波分析（PWA）和颈动脉内膜中层厚度（IMT），在慢性肾功能不全队列（CRIC）研究中招募的CKD患者队列中。在宾夕法尼亚大学研究中心的CRIC研究中入组的367例CKD受试者（平均年龄59.9岁，血压129/74 mm Hg，估计肾小球滤过率48 ml/min/1.73 m2，IMT 0.8 mm）进行了颈动脉IMT和PWA测量。颈动脉超声也用于确定斑块的存在。PWA测定增强指数（AI）、放大率（AMPR）、主动脉脉压（C_PP）和中心主动脉收缩压（C_SP）。IMT与所有PWA衍生测量值显著相关。然而，在多变量线性回归分析中，只有AMPR（回归系数为-0.072，P = 0.006）、C_PP（回归系数为0.0025，P < 0.001）和C_SP（回归系数为0.0017，P < 0.001）仍与IMT显著相关。队列中颈动脉斑块的患病率为59%。在PWA衍生的测量中，只有C_PP与颈动脉斑块的存在显著相关（P < 0.001）。PWA衍生测量与CKD患者颈动脉IMT和斑块相关。在这些指标中，C_PP与颈动脉IMT和斑块最相关。
Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. Three hundred and sixty-seven subjects with CKD enrolled in the CRIC study at the University of Pennsylvania site (mean age 59.9 years, blood pressure 129/74 mm Hg, estimated glomerular filtration rate 48 ml/min/1.73 m2, IMT 0.8 mm) had both carotid IMT and PWA measurements. Carotid ultrasound was also used to determine the presence of plaque. PWA was used to determine augmentation index (AI), amplification ratio (AMPR), aortic pulse pressure (C_PP), and central aortic systolic pressure (C_SP). IMT was significantly associated with all PWA-derived measures. However, on multivariable linear regression analysis, only AMPR (regression coefficient −0.072, P = 0.006), C_PP (regression coefficient 0.0025, P < 0.001), and C_SP (regression coefficient 0.0017, P < 0.001) remained significantly associated with IMT. The prevalence of carotid plaque in the cohort was 59%. Of the PWA-derived measures, only C_PP was significantly associated with the presence of carotid plaque (P < 0.001). PWA-derived measures are associated with carotid IMT and plaque in the CKD. Of these measures, C_PP was most associated with carotid IMT and plaque.
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影响因子：
8.3
作者：
McEniery, Carmel M.;McDonnell, Barry;Wilkinson, Ian B.
通讯作者：
Wilkinson, Ian B.
影响因子：
5
作者：
Chambless, LE;Heiss, G;Clegg, LX
通讯作者：
Clegg, LX
DOI：
10.1161/01.atv.8.6.788
发表时间：
1988-11-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
SALONEN, R;SEPPANEN, K;SALONEN, JT
通讯作者：
SALONEN, JT
影响因子：
8.3
作者：
Pauca, AL;O'Rourke, MF;Kon, ND
通讯作者：
Kon, ND
影响因子：
37.8
作者：
Franklin, SS;Khan, SA;Levy, D
通讯作者：
Levy, D