Neutralization of Enterovirus D68 isolated from the 2014 US outbreak by commercial intravenous immune globulin products.
Neutralization of Enterovirus D68 isolated from the 2014 US outbreak by commercial intravenous immune globulin products.
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通过商业静脉免疫球蛋白产品从2014年美国暴发中分离出的肠病毒D68中和肠病毒病毒D68。
DOI：
10.1016/j.jcv.2015.06.086
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Weldon WC
中科院分区：
文献类型：
--
作者：
Zhang Y;Moore DD;Nix WA;Oberste MS;Weldon WC
In 2014, an outbreak of Enterovirus D68 (EV-D68) was recorded as the largest in the United States with cases confirmed in 49 states. Intravenous immune globulin (IVIG) has been used to treat enterovirus infections in neonates and is an accepted replacement therapy for immunodeficient patients. This study aimed to detect the presence of neutralizing antibodies to EV-D68 viruses from the 2014 outbreak in commercially available IVIG products. Commercially available lots of IVIG preparations were obtained from five different manufacturers (2–10 preparations per manufacturer) and tested for neutralizing antibodies against the prototype EV-D68 virus and three EV-D68 isolates representing strains circulating during the 2014 outbreak. All lots of IVIG tested were positive for EV-D68 neutralizing antibodies, with high titers ranging from 9.5 log2 to 17.5 log2, and with comparable median titers to all four EV-D68 viruses. Amino acid sequence differences in the regions of the predicted antigenic sites on the viral capsid may explain some of the differences in neutralization among the different strains. The neutralization titers suggests that the 2014 outbreak EV-D68 viruses share some antigenic sites with the prototype virus and also present some unique antigenic sites distinct from the prototype. However, the commercial IVIG lots tested all contained high levels of neutralizing antibodies against EV-D68.
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影响因子：
11.8
作者：
ABZUG, MJ;KEYSERLING, HL;ROTBART, HA
通讯作者：
ROTBART, HA
影响因子：
9.6
作者：
Hung, Ivan F. N.;To, Kelvin K. W.;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
1.7
作者：
Wu, Chi-Yu;Wang, Hsiu-Chi;Wang, Der-Yuan
通讯作者：
Wang, Der-Yuan
DOI：
10.1016/s0731-7085(99)00087-4
发表时间：
1999-09-01
影响因子：
3.4
作者：
Lamari, F;Anastassiou, ED;Karamanos, NK
通讯作者：
Karamanos, NK
影响因子：
5.4
作者：
SHERRY, B;MOSSER, AG;RUECKERT, RR
通讯作者：
RUECKERT, RR