Linear coding of complex sound spectra by discharge rate in neurons of the medial nucleus of the trapezoid body (MNTB) and its inputs.
Linear coding of complex sound spectra by discharge rate in neurons of the medial nucleus of the trapezoid body (MNTB) and its inputs.
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DOI：
10.3389/fncir.2014.00144
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发表时间：
2014
影响因子：
3.5
通讯作者：
Tollin DJ
中科院分区：
文献类型：
--
作者：
Koka K;Tollin DJ
对声音位置的耳间水平差（ILD）提示首先在外侧上级橄榄（LSO）中编码。ILD敏感性的结果，因为LSO接收来自同侧耳蜗核的兴奋性输入和通过同侧斜方体内侧核（MNTB）的甘氨酸能神经元间接来自对侧耳蜗核的抑制性输入。据推测，为了使LSO神经元编码ILD，双耳处的声谱必须由其传入通过尖峰速率准确地编码。这种频谱编码假设尚未在MNTB中直接测试，可能是因为MNTB神经元最近主要描述和研究了它们编码声音的时间方面的能力，而不是频谱。在这里，我们测试的假设，MNTB神经元和它们的输入耳蜗核和听觉神经编码的声音频谱通过放电率。随机频谱形状（RSS）的方法被用来估计100毫秒的持续时间频谱稳定的刺激的水平是如何加权，线性和非线性，在一个宽频带的频率。在一般情况下，MNTB神经元，和他们的球状浓密细胞的输入，被发现是很好的建模的线性加权的频谱表明，通过MNTB的途径可以准确地编码声音频谱，包括那些从声音线索的声音位置提供的头部相关的方向传递函数（DTFs）。连同用于MNTB-LSO复合体中的定时的解剖学和生物物理学专业化，这些机制可以允许针对具有快速频谱时间调制包络的复杂刺激（诸如语音和动物发声以及移动声源）来计算ILD。
The interaural level difference (ILD) cue to sound location is first encoded in the lateral superior olive (LSO). ILD sensitivity results because the LSO receives excitatory input from the ipsilateral cochlear nucleus and inhibitory input indirectly from the contralateral cochlear nucleus via glycinergic neurons of the ipsilateral medial nucleus of the trapezoid body (MNTB). It is hypothesized that in order for LSO neurons to encode ILDs, the sound spectra at both ears must be accurately encoded via spike rate by their afferents. This spectral-coding hypothesis has not been directly tested in MNTB, likely because MNTB neurons have been mostly described and studied recently in regards to their abilities to encode temporal aspects of sounds, not spectral. Here, we test the hypothesis that MNTB neurons and their inputs from the cochlear nucleus and auditory nerve code sound spectra via discharge rate. The Random Spectral Shape (RSS) method was used to estimate how the levels of 100-ms duration spectrally stationary stimuli were weighted, both linearly and non-linearly, across a wide band of frequencies. In general, MNTB neurons, and their globular bushy cell inputs, were found to be well-modeled by a linear weighting of spectra demonstrating that the pathways through the MNTB can accurately encode sound spectra including those resulting from the acoustical cues to sound location provided by head-related directional transfer functions (DTFs). Together with the anatomical and biophysical specializations for timing in the MNTB-LSO complex, these mechanisms may allow ILDs to be computed for complex stimuli with rapid spectrotemporally-modulated envelopes such as speech and animal vocalizations and moving sound sources.
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DOI：
10.1007/s003590050146
发表时间：
1997-12-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
影响因子：
--
作者：
Ehret, G;Schreiner, CE
通讯作者：
Schreiner, CE
影响因子：
2.8
作者：
Greene, Nathaniel T.;Anbuhl, Kelsey L.;Williams, Whitney;Tollin, Daniel J.
通讯作者：
Tollin, Daniel J.
影响因子：
5.5
作者：
FORSYTHE, ID
通讯作者：
FORSYTHE, ID
影响因子：
5.3
作者：
Futai, K;Okada, M;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
2.8
作者：
GUINAN, JJ;LI, RYS
通讯作者：
LI, RYS