Calcium Signaling in Vertebrate Development and Its Role in Disease.
Calcium Signaling in Vertebrate Development and Its Role in Disease.
复制标题
DOI：
10.3390/ijms19113390
复制
发表时间：
2018-10-30
影响因子：
5.6
通讯作者：
Saha M
中科院分区：
文献类型：
--
作者：
Paudel S;Sindelar R;Saha M
过去三十年的积累证据表明，发育过程中钙信号的改变可能是成人病理生理事件的主要驱动力。超过100个人类基因编码专门用于钙稳态和钙信号传递的蛋白质，其中大部分在胚胎发育期间表达。分子技术的最新进展已经确定了发育过程中钙信号的受损，这是由于这些蛋白的突变或失调造成的。这种受损的信号与从心脏畸形到癫痫等各种人类疾病有关。尽管这些疾病和其他疾病的分子基础已经在成人系统中得到了很好的研究，但这些疾病的潜在发育起源还没有得到很好的表征。在这篇综述中，我们将讨论最近的证据，检查早期发育中不同的钙活动模式，以及与其失调相关的潜在医学条件。使用包括斑马鱼、非洲爪哇和小鼠在内的各种模式生物进行的研究强调了钙活动在不孕不育、流产、发育缺陷和一系列晚年出现的疾病中的关键作用。了解钙调节这些不同发育过程的潜在机制仍然是一个挑战；然而，这一知识可能使钙信号成为再生和个性化医学中的治疗靶点。
Accumulating evidence over the past three decades suggests that altered calcium signaling during development may be a major driving force for adult pathophysiological events. Well over a hundred human genes encode proteins that are specifically dedicated to calcium homeostasis and calcium signaling, and the majority of these are expressed during embryonic development. Recent advances in molecular techniques have identified impaired calcium signaling during development due to either mutations or dysregulation of these proteins. This impaired signaling has been implicated in various human diseases ranging from cardiac malformations to epilepsy. Although the molecular basis of these and other diseases have been well studied in adult systems, the potential developmental origins of such diseases are less well characterized. In this review, we will discuss the recent evidence that examines different patterns of calcium activity during early development, as well as potential medical conditions associated with its dysregulation. Studies performed using various model organisms, including zebrafish, Xenopus, and mouse, have underscored the critical role of calcium activity in infertility, abortive pregnancy, developmental defects, and a range of diseases which manifest later in life. Understanding the underlying mechanisms by which calcium regulates these diverse developmental processes remains a challenge; however, this knowledge will potentially enable calcium signaling to be used as a therapeutic target in regenerative and personalized medicine.
登录
查看更多内容
影响因子：
2.6
作者：
Cellot G;Cherubini E
通讯作者：
Cherubini E
DOI：
10.1016/j.devbrainres.2004.03.016
发表时间：
2004-07-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Creton, R
通讯作者：
Creton, R
影响因子：
10.4
作者：
Chen, W.;Thielmann, I.;Braun, A.
通讯作者：
Braun, A.
影响因子：
4
作者：
Bernhardt, Miranda L.;Zhang, Yingpei;Williams, Carmen J.
通讯作者：
Williams, Carmen J.
影响因子：
56.9
作者：
BOUCEK, MM;SNYDERMAN, R
通讯作者：
SNYDERMAN, R