Discrimination of dementia with Lewy bodies from Alzheimer's disease using voxel-based morphometry of white matter by statistical parametric mapping 8 plus diffeomorphic anatomic registration through exponentiated Lie algebra.
Discrimination of dementia with Lewy bodies from Alzheimer's disease using voxel-based morphometry of white matter by statistical parametric mapping 8 plus diffeomorphic anatomic registration through exponentiated Lie algebra.
复制标题
DOI：
10.1007/s00234-013-1138-9
复制
发表时间：
2013-05
期刊：
影响因子：
2.8
通讯作者：
Terada, Hitoshi
中科院分区：
文献类型：
--
作者：
Nakatsuka, Tomoya;Imabayashi, Etsuko;Matsuda, Hiroshi;Sakakibara, Ryuji;Inaoka, Tsutomu;Terada, Hitoshi
关键词：
本研究的目的是确定路易体痴呆（DLB）特异性脑萎缩，并评估这种特异性脑萎缩在DLB和阿尔茨海默病（AD）之间的区别表现。我们回顾性分析了60例DLB和30例AD患者接受了3D t1加权MRI。我们将DLB患者随机分为A、B两组。首先，我们利用基于统计参数映射8 （SPM8）的基于体素的阿尔茨海默病特异性区域分析系统（VSRAD）计算的显著全白质（WM）萎缩的百分比进行相关分析，并通过指数李代数进行微分形态解剖配准，获得了dlb特异性萎缩的目标兴趣体积（VOI）。然后，我们评估了该目标VOI在区分B组剩余30名DLB患者和30名AD患者方面的有用性。在受试者工作特征（ROC）分析中，使用VSRAD获得的该目标VOI的Z分值作为决定因素。DLB的特异性靶voi在右侧优势中脑背侧、右侧优势脑桥背侧和双侧小脑。ROC分析显示，在0.75的ROC曲线下，仅限于中脑的目标VOI面积最大。DLB患者表现出中脑、脑桥和小脑的特异性萎缩。中脑萎缩表现出区分DLB和AD的最高能力。这种方法可能有助于确定DLB和AD病理对痴呆综合征的贡献。
The purpose of this study was to identify brain atrophy specific for dementia with Lewy bodies (DLB) and to evaluate the discriminatory performance of this specific atrophy between DLB and Alzheimer’s disease (AD). We retrospectively reviewed 60 DLB and 30 AD patients who had undergone 3D T1-weighted MRI. We randomly divided the DLB patients into two equal groups (A and B). First, we obtained a target volume of interest (VOI) for DLB-specific atrophy using correlation analysis of the percentage rate of significant whole white matter (WM) atrophy calculated using the Voxel-based Specific Regional Analysis System for Alzheimer’s Disease (VSRAD) based on statistical parametric mapping 8 (SPM8) plus diffeomorphic anatomic registration through exponentiated Lie algebra, with segmented WM images in group A. We then evaluated the usefulness of this target VOI for discriminating the remaining 30 DLB patients in group B from the 30 AD patients. Z score values in this target VOI obtained from VSRAD were used as the determinant in receiver operating characteristic (ROC) analysis. Specific target VOIs for DLB were determined in the right-side dominant dorsal midbrain, right-side dominant dorsal pons, and bilateral cerebellum. ROC analysis revealed that the target VOI limited to the midbrain exhibited the highest area under the ROC curves of 0.75. DLB patients showed specific atrophy in the midbrain, pons, and cerebellum. Midbrain atrophy demonstrated the highest power for discriminating DLB and AD. This approach may be useful for determining the contributions of DLB and AD pathologies to the dementia syndrome.
登录
查看更多内容
影响因子：
2.4
作者：
Small, GW
通讯作者：
Small, GW
DOI：
10.1016/j.jalz.2011.03.004
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jack CR Jr;Albert MS;Knopman DS;McKhann GM;Sperling RA;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH
影响因子：
9.9
作者：
Cousins, DA;Burton, EJ;O'Brien, JT
通讯作者：
O'Brien, JT
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM
影响因子：
3.3
作者：
Jellinger, KA
通讯作者：
Jellinger, KA