Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
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DOI：
10.1016/j.jalz.2011.03.004
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Phelps CH
中科院分区：
文献类型：
--
作者：
Jack CR Jr;Albert MS;Knopman DS;McKhann GM;Sperling RA;Carrillo MC;Thies B;Phelps CH
阿尔茨海默病（AD）的临床诊断标准由国家神经和交流障碍和中风研究所（NINCDS）和阿尔茨海默病及相关疾病协会（ADRDA）于1984年建立[1]。这些标准被普遍采用，非常有用，并且在世纪的时间里没有经过任何修改。然而，在这27年中，我们对AD的理解取得了重要进展，我们检测AD的病理生理过程的能力，以及关于该疾病临床谱的概念化的变化已经发生了，到2009年，学术界和工业界普遍认为应该修改标准以纳入该领域的科学进展。为了应对这一迫切需要，国家老龄问题研究所和阿尔茨海默氏症协会在2009年主办了一系列咨询圆桌会议，其目的是建立一个修订阿尔茨海默氏症连续体诊断和研究标准的进程。这些咨询会议的成员包括来自学术界和工业界的国际代表。咨询会议的共识是，应在国家评估机构和AA的主持下成立三个独立的工作组。一个工作组被分配的任务，制定诊断标准的痴呆阶段的AD。第二个被要求专注于AD的症状性痴呆前期的诊断标准。第三位专家被要求提出一个研究议程的无症状，临床前阶段的AD。由NIA和AA选择个人在这些工作组中任职，目的是平衡学术界和工业界的专业知识和国际代表性。从2010年初到年中，三个工作组通过电话会议和亲自（在可行的情况下）举行会议。每个小组都提出了一套建议。这些建议在2010年ICAD会议的一次专题讨论会上提出。2010年夏天，他们在阿尔茨海默氏症协会的网站上发表了一段时间的公众评论。在此期间从网站和其他渠道收到的评论意见已提交给各个工作组，并在2010年秋季纳入每份文件的修订稿。最后，要求一个代表每个工作组成员的小组委员会审查各项建议，特别是关于生物标志物的方法的建议，并于2010年秋末对每份文件进行了最后一轮修订，目的是
Criteria for the clinical diagnosis of Alzheimer’s Disease (AD) were established by a National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the Alzheimer’s Disease and Related Disorders Association (ADRDA) workgroup in 1984 [1]. These criteria were universally adopted, have been extremely useful, and have survived intact without modification for over a quarter of a century. In the intervening 27 years, however, important advances in our understanding of AD, in our ability to detect the pathophysiological process of AD, and changes in conceptualization regarding the clinical spectrum of the disease have occurred.By 2009 broad consensus existed throughout academia and industry that the criteria should be revised to incorporate scientific advances in the field. In response to this imperative the National Institute on Aging (NIA) and the Alzheimer’s Association (AA) sponsored a series of advisory round table meetings in 2009 whose purpose was to establish a process for revising diagnostic and research criteria for the continuum of AD. These advisory meetings included members from academia and industry with an international representation. The consensus from the advisory meetings was that three separate work groups should be formed under the auspices of the NIA and AA. One work group was assigned the task of formulating diagnostic criteria for the dementia phase of AD. A second was asked to focus on diagnostic criteria for the symptomatic pre-dementia phase of AD. The third workgroup was asked to propose a research agenda for the asymptomatic, preclinical phase of AD. Individuals were selected to serve in these work groups, by the NIA and the AA, with the objective of having balanced expertise and international representation from academia and industry. From early to mid 2010 the three work groups met via conference call and in person (as feasible). Each formulated a set of recommendations. These recommendations were presented in a symposium at the 2010 ICAD meeting. They were posted on the Alzheimer’s Association website for a period of public comment over the summer of 2010. Comments received during this period, from the website and other venues, were given to the individual workgroups and incorporated into revisions of each document in the fall of 2010. Lastly, a subcommittee representing individuals from each of the workgroups was asked to review the recommendations, particularly with regard to the approach to biomarkers, and a final round of revisions was made to each document in the late fall of 2010 for purposes of
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影响因子：
4.2
作者：
Hyman, BT
通讯作者：
Hyman, BT
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.
影响因子：
9.9
作者：
Bennett, DA;Schneider, JA;Wilson, RS
通讯作者：
Wilson, RS
影响因子：
11.2
作者：
DEKOSKY, ST;SCHEFF, SW
通讯作者：
SCHEFF, SW
影响因子：
5.3
作者：
Buckner, RL;Snyder, AZ;Mintun, MA
通讯作者：
Mintun, MA