Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core.
Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core.
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DOI：
10.1111/j.1460-9568.2008.06517.x
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Janak PH
中科院分区：
文献类型：
--
作者：
Chaudhri N;Sahuque LL;Cone JJ;Janak PH
与乙醇不可得性相关的环境相比，在与先前乙醇自我给药(SA)相关的环境中，由乙醇预测性光调刺激诱导的乙醇(Etoh)寻找的恢复(Etoh)被增强。在这里，我们假设寻找乙醇将由乙醇的条件性感觉刺激特性引发，这种恢复也将类似地受到语境的调节。我们还确定了药物失活伏隔核(NAC)，这是复发回路中的关键结构，是否会减弱恢复的乙醇寻找。在特定的视觉、嗅觉和触觉刺激的操作条件室中，大鼠被杠杆压迫以口服乙醇(10%v/v)。然后，在另一个不同的背景下，通过扣留Etoh来终止回应。随后，在消光或先前的乙醇-SA上下文中，通过提供口服乙醇底物(两个等量的0.1毫升乙醇)来测试乙醇寻找，表现为在没有乙醇输送的情况下反应增强。在恢复测试前立即将生理盐水或γ-氨基丁酸激动剂(麝香酚/巴氯芬)微量注入大鼠NAc核或壳内(0.3μL/半球)。在先前的乙醇-SA中观察到了强劲的乙醇寻找，但在盐水预处理的大鼠中没有观察到灭绝背景。这种影响可以通过使NAC核心失活而不是外壳来显著减弱。相反，在灭绝背景下，NAC壳的失活显著增加了杠杆压力。这些数据表明，当在适当的环境中经历时，口服乙醇的感觉刺激特性可以恢复乙醇寻求，而NAC核心的功能活动是实现这一效果所必需的。相反，外壳通常可能会抑制不正确的行为反应。
The reinstatement of ethanol (EtOH)-seeking induced by an EtOH-predictive light-tone stimulus is enhanced in an environment associated with prior EtOH self-administration (SA) compared with a context associated with EtOH unavailability. Here we hypothesized that EtOH-seeking would be elicited by the conditioned sensory stimulus properties of EtOH and that this reinstatement would be similarly modulated by context. We also determined whether pharmacologically inactivating the nucleus accumbens (NAc), a key structure in relapse circuitry, would attenuate reinstated EtOH-seeking. Rats lever-pressed for oral EtOH (10% v/v) in operant conditioning chambers distinguished by specific visual, olfactory and tactile stimuli. Responding was then extinguished by withholding EtOH in a different context. EtOH-seeking, expressed as elevated responding without EtOH delivery, was subsequently tested by presenting an oral EtOH prime (two aliquots of 0.1 mL EtOH) in either the extinction or the prior EtOH-SA context. Rats received a microinfusion (0.3 μL/hemisphere) of saline or GABA agonists (muscimol/baclofen) into the NAc core or shell immediately before the reinstatement test. Robust EtOH-seeking was observed in the prior EtOH-SA but not the extinction context in saline-pretreated rats. This effect was significantly attenuated by inactivating the NAc core but not shell. Conversely, NAc shell inactivation significantly elevated lever-pressing in the extinction context. These data suggest that the sensory stimulus properties of oral EtOH can reinstate EtOH-seeking when experienced in the appropriate context and that functional activity in the NAc core is required for this effect. In contrast, the shell may normally inhibit incorrect behavioral responses.
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DOI：
10.1196/annals.1390.006
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
Balleine, Bernard W.;Ostlund, Sean B.
通讯作者：
Ostlund, Sean B.
影响因子：
3.4
作者：
Bassareo, V;De Luca, MA;Di Chiara, G
通讯作者：
Di Chiara, G
DOI：
10.1073/pnas.0706999105
发表时间：
2008-08-26
影响因子：
11.1
作者：
Bowers, M. Scott;Hopf, F. Woodward;Diamond, Ivan
通讯作者：
Diamond, Ivan
影响因子：
5.3
作者：
Floresco, SB;Ghods-Sharifi, S;Magyar, O
通讯作者：
Magyar, O
DOI：
10.1097/01.alc.0000080666.89573.73
发表时间：
2003-08-01
影响因子：
3.2
作者：
Davidson, D;Tiffany, ST;Li, TK
通讯作者：
Li, TK