Thiamine deficiency in Gambian women of reproductive age.
Thiamine deficiency in Gambian women of reproductive age.
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DOI：
10.1111/nyas.14695
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发表时间：
2022-01
影响因子：
5.2
通讯作者：
Cerami, Carla
中科院分区：
文献类型：
--
作者：
Bourassa, Megan W.;Gomes, Filomena;Jones, Kerry S.;Koulman, Albert;Prentice, Andrew M.;Cerami, Carla
硫胺素缺乏症与影响神经和心血管系统的各种临床症状有关。越来越多的人认识到，硫胺素缺乏症可能发生在南亚经典地区以外的人群中，高危人群包括那些从抛光白色大米（或其他低硫胺素主食）中获得大部分能量的人，以及饮食多样性低的人。在过去的世纪中，关于西非硫胺素缺乏症的报告表明，这在历史上一直是这一人群的一个问题，但在最近几十年，这些报告仅限于监狱人口。为了了解是否硫胺素缺乏症可能是一个未被认识到的问题，在该地区的社区，红细胞样本收集在雨季和旱季从226名育龄妇女（平均年龄= 28岁）进行了评估硫胺素的状态，通过测量红细胞转酮醇酶活性系数（ETKac）。总体而言，35.8%的样本处于硫胺素缺乏症的高风险（ETKac ≥ 1.25）。丰水期硫胺素缺乏的风险（47.9%）显著高于旱季（22.9%）（P < 0.001）。据我们所知，这是世纪西非自由生活人群中第一份生化硫胺素缺乏症的报告，并建议进一步调查。为了了解是否硫胺素缺乏症可能是一个未被认识到的问题，在西非，红细胞样本收集在雨季和旱季冈比亚育龄妇女进行了评估硫胺素的状态，通过测量红细胞转酮醇酶活性系数。据我们所知，这是世纪首次对西非自由生活人群中的生化硫胺素缺乏症进行研究。
Thiamine deficiency disorders are associated with a variety of clinical symptoms affecting the nervous and cardiovascular systems. There is growing recognition that thiamine deficiency can occur in populations well beyond the classical region of South Asia, and at‐risk populations include those who receive a large proportion of their energy from polished white rice (or other low‐thiamine staple foods) and with low dietary diversity. Reports of thiamine deficiency in West Africa over the last century have suggested that this has historically been an issue in this population, but in more recent decades, these reports have been limited to prison populations. To understand if thiamine deficiency might be an unrecognized problem in the communities of this region, erythrocyte samples collected during the wet and dry seasons from 226 women of reproductive age (mean age = 28 years old) were assessed for thiamine status by measuring the erythrocyte transketolase activity coefficient (ETKac). Overall, 35.8% of the sample was at high risk of thiamine deficiency (ETKac ≥ 1.25). Risk of thiamine deficiency was significantly higher in the wet (47.9%) compared with the dry season (22.9%) (P < 0.001). To our knowledge, this is the first report of biochemical thiamine deficiency in a free‐living population in West Africa in the 21st century and suggests that further investigation is warranted. To understand if thiamine deficiency might be an unrecognized problem in West Africa, erythrocyte samples collected during the wet and dry seasons from Gambian women of reproductive age were assessed for thiamine status by measuring the erythrocyte transketolase activity coefficient. To our knowledge, this is the first study of biochemical thiamine deficiency in a free‐living population in West Africa in the 21st century.
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影响因子：
5.2
作者：
Jones KS;Parkington DA;Cox LJ;Koulman A
通讯作者：
Koulman A
影响因子：
5.2
作者：
Koshy, Roshine Mary;Thankaraj, Shajin;Solomi, Carolin V.
通讯作者：
Solomi, Carolin V.
影响因子：
0.5
作者：
Hiffler, L.;Escajadillo, K.;Janet, S.
通讯作者：
Janet, S.
影响因子：
3.4
作者：
Harel, Yael;Zuk, Luba;Fattal-Valevski, Aviva
通讯作者：
Fattal-Valevski, Aviva
DOI：
10.1038/nrendo.2016.37
发表时间：
2016-05
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Gernand AD;Schulze KJ;Stewart CP;West KP Jr;Christian P
通讯作者：
Christian P