Molecular mechanisms underlying monosynaptic sensory-motor circuit development in the spinal cord.
Molecular mechanisms underlying monosynaptic sensory-motor circuit development in the spinal cord.
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DOI：
10.1002/dvdy.24611
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Yoshida Y
中科院分区：
文献类型：
--
作者：
Imai F;Yoshida Y
中枢神经系统(CNS)中感觉和运动系统的整合精确地控制着运动行为。本体感觉神经元是感觉系统的重要组成部分，位于背根神经节内，轴突向脊髓中央投射，向肌肉和肌腱投射，向中枢神经系统传递有关身体的外周信息。肌梭检测到的肌肉长度变化和高尔基肌腱器官传递的肌腱张力变化分别通过Ia/II组和Ib本体感觉传入传递到中枢神经系统。Ib组本体感觉神经元通过脊髓间神经元与运动神经元间接连接，而Ia/II组轴突与运动神经元形成直接(单突触)和间接连接。尽管自20世纪50年代以来，纺锤本体感觉神经元和运动神经元之间的单突触感觉-运动神经回路已经得到了广泛的研究，但其形成和维持的分子机制直到最近才开始被了解。我们将讨论我们目前对哺乳动物脊髓中涉及本体感觉神经元和运动神经元的单突触回路发育和维持的分子基础的理解。
Motor behaviors are precisely controlled by the integration of sensory and motor systems in the central nervous system (CNS). Proprioceptive sensory neurons, key components of the sensory system, are located in the dorsal root ganglia and project axons both centrally to the spinal cord and peripherally to muscles and tendons, communicating peripheral information about the body to the CNS. Changes in muscle length detected by muscle spindles, and tension variations in tendons conveyed by golgi tendon organs, are communicated to the CNS through group Ia/II, and Ib proprioceptive sensory afferents, respectively. Group Ib proprioceptive sensory neurons connect with motor neurons indirectly via spinal interneurons, whereas group Ia/II axons form both direct (monosynaptic) and indirect connections with motor neurons. Although monosynaptic sensory-motor circuits between spindle proprioceptive sensory neurons and motor neurons have been extensively studied since 1950s, the molecular mechanisms underlying their formation and upkeep have only recently begun to be understood. We will discuss our current understanding of the molecular foundation of monosynaptic circuit development and maintenance involving proprioceptive sensory neurons and motor neurons in the mammalian spinal cord.
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作者：
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DOI：
10.1073/pnas.1419045111
发表时间：
2014-11-25
影响因子：
11.1
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