Endocan, sepsis, pneumonia, and acute respiratory distress syndrome.
Endocan, sepsis, pneumonia, and acute respiratory distress syndrome.
复制标题
DOI：
10.1186/s13054-018-2222-7
复制
发表时间：
2018-10-26
期刊：
影响因子：
--
通讯作者：
Lassalle P
中科院分区：
文献类型：
--
作者：
De Freitas Caires N;Gaudet A;Portier L;Tsicopoulos A;Mathieu D;Lassalle P
急性呼吸窘迫综合征（ARDS）和医院获得性肺炎（HAP）是重症监护病房（ICU）的主要公共卫生问题，15%的危重患者出现这种情况。在解释 ARDS 发展的因素中，脓毒症是一种常见原因。脓毒症、ARDS 和 HAP 会增加发病率、死亡率、入住 ICU 的时间以及总体医疗费用。主要挑战仍然是在危重患者中准确识别那些有不良结果风险的患者，这些患者可以从新疗法中受益。 Endocan 由肺内皮释放以响应局部或全身损伤。在体外和体内，它主要抑制白细胞渗出，而不是白细胞滚动或与内皮细胞的粘附。 Endocan 在 25 份临床报告中进行了评估，其中包括 2454 名危重患者和 452 名健康对照者。 Endocan对脓毒症或脓毒症严重程度的诊断价值与降钙素原相当，但其预后价值更好。两项研究证明了术后肺炎的预测价值，三个独立中心的四项研究证明了 ARDS 的预测价值。本综述概述了 Endocan 的结构、表达和功能。我们还总结了endocan在ARDS和HAP的预测和预后以及脓毒症预后中的潜在应用。
Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the factors explaining ARDS development, sepsis is known as a frequent cause. Sepsis, ARDS, and HAP increase morbidity, mortality, length of stay in the ICU, and the overall costs of healthcare. The major challenge remains to identify accurately among critically ill patients those at risk of poor outcomes who could benefit from novel therapies. Endocan is released by the pulmonary endothelium in response to local or systemic injury. It inhibits mainly leukocyte diapedesis rather than leukocyte rolling or adhesion to the endothelial cells both in vitro and in vivo. Endocan was evaluated in 25 clinical reports, including 2454 critically ill patients and 452 healthy controls. The diagnostic value of endocan for sepsis or sepsis severity was equal to procalcitonin but its prognostic value was better. A predictive value for postoperative pneumonia was evidenced in two studies, and a predictive value for ARDS in four studies from three independent centers. This review presents an overview of the structure, expression, and functions of endocan. We also hereby summarize the potential applications of endocan in the prediction and prognosis of ARDS and HAP, as well as in the prognosis of sepsis.
登录
查看更多内容
影响因子：
76.2
作者：
Calfee, Carolyn S.;Delucchi, Kevin;Parsons, Polly E.;Thompson, B. Taylor;Ware, Lorraine B.;Matthay, Michael A.
通讯作者：
Matthay, Michael A.
DOI：
10.1164/rccm.201603-0645oc
发表时间：
2017-02-01
影响因子：
24.7
作者：
Famous, Katie R.;Delucchi, Kevin;Calfee, Carolyn S.
通讯作者：
Calfee, Carolyn S.
影响因子：
8.8
作者：
Jebali, Mohamed Adel;Hausfater, Pierre;Ferjani, Mustapha
通讯作者：
Ferjani, Mustapha
影响因子：
2.7
作者：
Jiao, Jia;Wang, Min;Zhou, Xinmin
通讯作者：
Zhou, Xinmin
影响因子：
3.8
作者：
Madhivathanan, Pradeep R.;Fletcher, Nick;Sharma, Vivek
通讯作者：
Sharma, Vivek