Gene therapy as future treatment of erectile dysfunction.
Gene therapy as future treatment of erectile dysfunction.
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DOI：
10.1517/14712598.2010.510510
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发表时间：
2010-09
影响因子：
4.6
通讯作者：
Glorioso JC
中科院分区：
文献类型：
--
作者：
Yoshimura N;Kato R;Chancellor MB;Nelson JB;Glorioso JC
勃起功能障碍（ED）是一个主要的男性健康问题。尽管磷酸二酯酶5 （PDE5）抑制剂治疗ED的成功率很高，但仍有大量ED患者对目前可用的治疗方式没有反应。为了解基因治疗在ED中的应用现状，本文综述了ED的基因治疗方法。基因治疗策略可以增强一氧化氮（NO）的产生或NO介导的信号通路，生长因子介导的神经再生或平滑肌中K+通道的活性，这可能是治疗ED的有希望的方法。尽管大多数基因治疗研究仍处于临床前阶段，但首次使用非病毒基因转移Ca2+激活的大电导K+通道进入ED患者的海肌体的临床试验显示出积极的结果。基因治疗代表了ED的一个令人兴奋的未来治疗选择，特别是对于那些对当前一线治疗（如PDE5抑制剂）无反应的严重ED患者，尽管病毒和非病毒基因治疗的长期安全性有待确定。
Erectile dysfunction (ED) is a major men’s health problem. Although the high success rate of treating ED by phosphodiesterase 5 (PDE5) inhibitors has been reported, there are a significant number of ED patients who do not respond to currently available treatment modalities. To understand the current status of gene therapy application for ED, gene therapy approaches for ED treatment are reviewed. Gene therapy strategies that can enhance nitric oxide (NO) production or NO-mediated signaling pathways, growth factor-mediated nerve regeneration or K+ channel activity in the smooth muscle could be promising approaches for the treatment of ED. Although the majority of gene therapy studies are still in the preclinical phase, the first clinical trial using non-viral gene transfer of Ca2+-activated, large-conductance K+ channels into the corpus cavernosum of ED patients showed positive results. Gene therapy represents an exciting future treatment option for ED, especially for people with severe ED unresponsive to current first-line therapies such as PDE5 inhibitors although the long-term safety of both viral and non-viral gene therapies should be established.
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DOI：
10.1152/ajpheart.1998.275.2.h600
发表时间：
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影响因子：
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