Association of oncological response between the first‐line chemotherapy and subsequent immune checkpoint inhibitors therapy in patients with unresectable or metastatic urothelial carcinoma
Association of oncological response between the first‐line chemotherapy and subsequent immune checkpoint inhibitors therapy in patients with unresectable or metastatic urothelial carcinoma
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不可切除或转移性尿路上皮癌患者一线化疗与后续免疫检查点抑制剂治疗之间肿瘤学反应的关联
DOI：
10.1111/iju.14778
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发表时间：
2021
影响因子：
2.6
通讯作者：
Ohyama Chikara
中科院分区：
文献类型：
--
作者：
Ozaki Kai;Hatakeyama Shingo;Hamaya Tomoko;Okita Kazutaka;Hashimoto Yasuhiro;Ohyama Chikara
ICI免疫检查点抑制剂OS总生存期PD进展性疾病UC尿路上皮癌晚期UC是一种预后不良的危及生命的疾病。1-3 ICI治疗对不可切除的局部晚期或转移性UC患者有益。4，5然而，有限的生物标志物可用于预测对ICI治疗的反应。(d)所有患者（n= 218）OS的多变量考克斯回归分析。gl本研究结果显示，与未接受ICI治疗的患者相比，一线化疗（非PD <= 4个周期）的良好肿瘤反应与后续ICI治疗患者的生存期延长显著相关。因此，我们回顾性研究了肿瘤对一线化疗的反应对晚期UC患者后续ICI治疗反应的影响。国际泌尿学杂志的版权是Wiley-Blackwell的财产，未经版权保持器的明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对副本的准确性不作任何保证。用户应参考材料的原始出版版本以获取完整摘要。版权适用于所有摘要。
Abbreviations & Acronyms ICI immune checkpoint inhibitor OS overall survival PD progressive disease UC urothelial carcinoma Advanced UC is a life-threatening disease with a poor prognosis. 1-3 ICIs therapy is beneficial in patients with unresectable locally advanced or metastatic UC. 4, 5 However, limited biomarkers are available to predict the response to ICIs therapy.(d) Multivariable Cox regression analysis for OS in all patients (n= 218). gl The present results showed the favorable tumor response to the first-line chemotherapy (non-PD <= 4 cycles) was significantly associated with longer survival in patients with subsequent ICIs therapy than those without. Therefore, we retrospectively investigated the effect of tumor response to the first-line chemotherapy on the response to the subsequent ICIs therapy in patients with advanced UC.[Extracted from the article]Copyright of International Journal of Urology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.
盆腔器官脱垂手术后计算机断层扫描图像上网格的可视化
影响因子：
2.6
作者：
A. Yamaguchi;K. Miwa;Kazuya Nakahira;Y. Moriyama;Y. Kitagawa
通讯作者：
Y. Kitagawa