Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.
Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.
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DOI：
10.1016/j.drugalcdep.2017.11.030
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发表时间：
2018-04-01
影响因子：
4.2
通讯作者：
Jones HE
中科院分区：
文献类型：
--
作者：
Kaltenbach K;O'Grady KE;Heil SH;Salisbury AL;Coyle MG;Fischer G;Martin PR;Stine S;Jones HE
美沙酮和丁丙诺啡被推荐用于治疗妊娠期间的阿片类药物使用障碍。然而，关于产前接触这些药物的长期影响与儿童发育之间关系的文献既少又不一致。参与者是96名儿童及其母亲，他们参加了母亲，这是一项妊娠期间阿片类药物激动剂药物治疗的随机对照试验。本研究调查了0 - 36个月儿童的生长参数、认知、语言能力、感觉处理和气质。母亲的育儿压力，家庭环境和成瘾的严重程度的看法也进行了检查。在三年期间，产前暴露于美沙酮与丁丙诺啡的儿童之间的平均差异检验产生了2/37的儿童显著结果。同样，对接受NAS治疗的儿童与未接受NAS治疗的儿童之间的平均差异进行检验，得出1/37的显著结果。随着时间的推移，27/37的儿童结局发生了变化，包括预期的儿童体重、头部和身高增加，以及认知发育、语言能力、感觉处理和气质的总体改善。对于母亲来说，随着时间的推移，父母的压力（9/17量表）的显着变化表明与孩子的困难越来越多，特别是在增加父母的压力，但也越来越丰富的家庭环境（4/7量表）。研究结果强烈表明，丁丙诺啡相对于美沙酮或治疗NAS严重程度相对于未治疗NAS对生长、认知发育、语言能力、感觉处理和气质无有害影响。此外，研究结果表明，产前阿片类激动剂暴露对正常的身心发育无害。
Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy. However, the literature on the relationship between longer-term effects of prenatal exposure to these medications and childhood development is both spare and inconsistent. Participants were 96 children and their mothers who participated in MOTHER, a randomized controlled trial of opioid-agonist pharmacotherapy during pregnancy. The present study examined child growth parameters, cognition, language abilities, sensory processing, and temperament from 0–36 months of the child’s life. Maternal perceptions of parenting stress, home environment, and addiction severity were also examined. Tests of mean differences between children prenatally exposed to methadone vs. buprenorphine over the three-year period yielded 2/37 significant findings for children. Similarly, tests of mean differences between children treated for NAS relative to those not treated for NAS yielded 1/37 significant finding. Changes over time occurred for 27/37 child outcomes including expected child increases in weight, head and height, and overall gains in cognitive development, language abilities, sensory processing, and temperament. For mothers, significant changes over time in parenting stress (9/17 scales) suggested increasing difficulties with their children, notably seen in increasing parenting stress, but also an increasingly enriched home environment (4/7 scales). Findings strongly suggest no deleterious effects of buprenorphine relative to methadone or of treatment for NAS severity relative to not-treated for NAS on growth, cognitive development, language abilities, sensory processing, and temperament. Moreover, findings suggest that prenatal opioid agonist exposure is not deleterious to normal physical and mental development.
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影响因子：
3.7
作者：
SIDAK, Z
通讯作者：
SIDAK, Z
DOI：
10.1016/s0889-8545(05)70362-4
发表时间：
1998-03-01
影响因子：
3.2
作者：
Kaltenbach, K;Berghella, V;Finnegan, L
通讯作者：
Finnegan, L
DOI：
10.1111/add.13462
发表时间：
2016-12
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Zedler BK;Mann AL;Kim MM;Amick HR;Joyce AR;Murrelle EL;Jones HE
通讯作者：
Jones HE
影响因子：
2.9
作者：
Patrick, S. W.;Davis, M. M.;Cooper, W. O.
通讯作者：
Cooper, W. O.
影响因子：
2.9
作者：
Bier, J. B.;Finger, A. S.;Coyle, M. G.
通讯作者：
Coyle, M. G.