Recent advances in delivery of drug-nucleic acid combinations for cancer treatment.
Recent advances in delivery of drug-nucleic acid combinations for cancer treatment.
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DOI：
10.1016/j.jconrel.2013.04.010
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发表时间：
2013-12-10
期刊：
影响因子：
--
通讯作者：
Oupický D
中科院分区：
文献类型：
--
作者：
Li J;Wang Y;Zhu Y;Oupický D
使用具有影响多个疾病途径的能力的方法的组合的癌症治疗已被证明在许多癌症的治疗中非常有效。联合治疗可以包括多种化学治疗剂或化学治疗剂与其他治疗方式如手术或放射的组合。然而，尽管联合治疗在临床上广泛使用，但对现代纳米载体递送方法（如脂质体、胶束和纳米颗粒）增强联合治疗疗效的潜力关注相对较少。这种知识的缺乏在用于递送核酸与传统小分子药物的组合的载体的有限成功中尤其显著。由于两种类型的药剂的物理化学性质的差异，药物-核酸组合的递送特别具有挑战性。本文综述了近年来小分子药物联合核酸治疗癌症的研究进展。本综述主要集中在用于选择适当的药物-核酸组合的基本原理以及适用于同时递送药物-核酸组合的纳米载体的开发进展。
Cancer treatment that uses a combination of approaches with the ability to affect multiple disease pathways has been proven highly effective in the treatment of many cancers. Combination therapy can include multiple chemotherapeutics or combinations of chemotherapeutics with other treatment modalities like surgery or radiation. However, despite the widespread clinical use of combination therapies, relatively little attention has been given to the potential of modern nanocarrier delivery methods, like liposomes, micelles, and nanoparticles, to enhance the efficacy of combination treatments. This lack of knowledge is particularly notable in the limited success of vectors for the delivery of combinations of nucleic acids with traditional small molecule drugs. The delivery of drug-nucleic acid combinations is particularly challenging due to differences in the physicochemical properties of the two types of agents. This review discusses recent advances in the development of delivery methods using combinations of small molecule drugs and nucleic acid therapeutics to treat cancer. This review primarily focuses on the rationale used for selecting appropriate drug-nucleic acid combinations as well as progress in the development of nanocarriers suitable for simultaneous delivery of drug-nucleic acid combinations.
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影响因子：
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