New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy.
New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy.
复制标题
肿瘤相关巨噬细胞促进肿瘤进展的新机制：最新研究进展和肿瘤免疫治疗的潜在靶点
DOI：
10.1155/2016/9720912
复制
发表时间：
2016
影响因子：
4.1
通讯作者：
Hua B
中科院分区：
文献类型：
--
作者：
Guo Q;Jin Z;Yuan Y;Liu R;Xu T;Wei H;Xu X;He S;Chen S;Shi Z;Hou W;Hua B
大多数基础和临床研究表明，肿瘤相关巨噬细胞（TAMs）具有促肿瘤功能，TAMs在基质细胞中占很大比例。TAM促进肿瘤的发生，其数量与多种肿瘤的恶性程度和不良预后有关。巨噬细胞的可塑性使得在肿瘤免疫治疗过程中改变肿瘤微环境和重塑抗肿瘤免疫成为可能。越来越多的研究已经揭示了TAM对肿瘤微环境的影响，例如，通过促进肿瘤生长和肿瘤发生以及通过增加癌症干细胞的数量或通过促进血管生成、淋巴管生成和转移。研究人员还提出了通过抑制TAM募集和分化、调节TAM极化以及阻断与TAM的促肿瘤功能相关的因子和途径来靶向TAM的肿瘤免疫治疗。这篇综合性综述介绍了最近关于TAM的研究，这些研究与不良结局的预测、肿瘤免疫微环境的重塑和免疫靶向治疗有关。
The majority of basic and clinical studies have shown a protumor function of tumor-associated macrophages (TAMs), which represent a large proportion of matrix cells. TAMs promote tumorigenesis, and their number is related to the malignancy degree and poor prognosis of many kinds of tumors. Macrophage plasticity makes it possible to change the tumor microenvironment and remodel antitumor immunity during cancer immunotherapy. Increasing numbers of studies have revealed the effects of TAMs on the tumor microenvironment, for example, via promotion of tumor growth and tumorigenesis and through an increase in the number of cancer stem cells or via facilitation of angiogenesis, lymphangiogenesis, and metastasis. Investigators also proposed tumor-immunological treatments targeting TAMs by inhibiting TAM recruitment and differentiation, by regulating TAM polarization, and by blocking factors and pathways associated with the protumor function of TAMs. This comprehensive review presents recent research on TAMs in relation to prediction of poor outcomes, remodeling of the tumor immune microenvironment, and immunological targeted therapies.
登录
查看更多内容
促进巨噬细胞存活和功能的胚胎干细胞对于畸胎瘤的发展至关重要
影响因子：
7.3
作者：
Chen T;Wang X;Guo L;Wu M;Duan Z;Lv J;Tai W;Renganathan H;Didier R;Li J;Sun D;Chen X;He X;Fan J;Young W;Ren Y
通讯作者：
Ren Y
DOI：
10.1016/j.bbrc.2016.01.002
发表时间：
2016-01-29
影响因子：
3.1
作者：
Choi, Hee-Jin;Choi, Hee-Jung;Ha, Ki-Tae
通讯作者：
Ha, Ki-Tae
影响因子：
50.3
作者：
Chen Q;Zhang XH;Massagué J
通讯作者：
Massagué J
影响因子：
7.2
作者：
Allavena P;Germano G;Belgiovine C;D'Incalci M;Mantovani A
通讯作者：
Mantovani A
影响因子：
4.8
作者：
Costa, Nadia Lago;Valadares, Marize Campos;Batista, Aline Carvalho
通讯作者：
Batista, Aline Carvalho