Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
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DOI：
10.1016/j.ccr.2011.08.025
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发表时间：
2011-10-18
期刊：
影响因子：
50.3
通讯作者：
Massagué J
中科院分区：
文献类型：
--
作者：
Chen Q;Zhang XH;Massagué J
乳腺癌细胞中血管细胞粘附分子-1（VCAM-1）的异常表达与肺复发相关，但VCAM-1作为转移介质的作用仍不清楚。我们报告说，VCAM-1为浸润富含白细胞的微环境（如肺部）的乳腺癌细胞提供了生存优势。VCAM-1通过反受体α4整合素将转移相关巨噬细胞拴系到癌细胞。细胞表面VCAM-1的聚集通过Ezrin起作用，触发Akt活化并保护癌细胞免受促凋亡细胞因子如TRAIL的影响。VCAM-1的这种促存活功能可被抗α4整联蛋白的抗体阻断。因此，表达VCAM-1的新播散的癌细胞可以通过VCAM-1-Ezrin-PI 3 K/Akt存活途径的阿曲他克林激活而在富含白细胞的微环境中茁壮成长。
Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has remained unknown. We report that VCAM-1 provides a survival advantage to breast cancer cells that infiltrate leukocyte-rich microenvironments such as the lungs. VCAM-1 tethers metastasis-associated macrophages to cancer cells via counter-receptor α4 integrins. Clustering of cell surface VCAM-1, acting through Ezrin, triggers Akt activation and protects cancer cells from pro-apoptotic cytokines such as TRAIL. This pro-survival function of VCAM-1 can be blocked by antibodies against α4 integrins. Thus, newly disseminated cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1–Ezrin-PI3K/Akt survival pathway.
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DOI：
10.1093/jnci/53.3.661
发表时间：
1974-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
CAILLEAU, R;YOUNG, R;REEVES, WJ
通讯作者：
REEVES, WJ
VCAM-1和ICAM-1与粘附白细胞的新型内皮对接结构中的动态相互作用。
DOI：
10.1083/jcb.200112126
发表时间：
2002-06-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Barreiro O;Yanez-Mo M;Serrador JM;Montoya MC;Vicente-Manzanares M;Tejedor R;Furthmayr H;Sanchez-Madrid F
通讯作者：
Sanchez-Madrid F
影响因子：
4.3
作者：
Ding, YB;Chen, GY;Yang, L
通讯作者：
Yang, L
DOI：
10.1073/pnas.88.17.7859
发表时间：
1991-09-01
影响因子：
11.1
作者：
CYBULSKY, MI;FRIES, JWU;COLLINS, T
通讯作者：
COLLINS, T
影响因子：
4
作者：
Anan, Keisei;Mitsuyama, Shoshu;Toyoshima, Satoshi
通讯作者：
Toyoshima, Satoshi