Increased risk of non-alcoholic fatty liver disease after diagnosis of celiac disease.
Increased risk of non-alcoholic fatty liver disease after diagnosis of celiac disease.
复制标题
DOI：
10.1016/j.jhep.2015.01.013
复制
发表时间：
2015-06
影响因子：
25.7
通讯作者：
Ludvigsson, Jonas F.
中科院分区：
文献类型：
--
作者：
Reilly, Norelle R.;Lebwohl, Benjamin;Hultcrantz, Rolf;Green, Peter H. R.;Ludvigsson, Jonas F.
非酒精性脂肪肝是慢性肝病的常见原因。乳糜泻会改变肠道通透性，无麸质饮食治疗通常会导致体重增加，但迄今为止，乳糜泻患者发生非酒精性脂肪肝的报道很少。基于人群的队列研究。我们将 1997 年至 2009 年期间诊断的乳糜泻患者 (n=26,816) 与匹配的参考个体 (n=130,051) 诊断的非酒精性脂肪肝风险进行了比较。在乳糜泻之前患有任何肝脏疾病的患者以及终生诊断为酒精相关疾病的个体都被排除在外，以尽量减少非酒精性脂肪肝疾病的错误分类。确定了 Cox 回归估计的非酒精性脂肪肝疾病的风险比。在 246,559 人年的随访中，53 名乳糜泻患者被诊断为非酒精性脂肪肝（21/100,000 人年）。相比之下，我们在 1,488,413 人年（6/100,000 人年）期间确定了 85 名被诊断患有非酒精性脂肪肝疾病的参考个体。这对应的风险比为 2.8 (95%CI=2.0-3.8)，其中儿童的风险估计值最高 (HR=4.6；95%CI=2.3-9.1)。乳糜泻诊断后第一年的风险增加为 13.3 (95%CI=3.5-50.3)，但即使在乳糜泻诊断后 15 年后，风险仍显着升高 (HR=2.5；95%CI 1.0-5.9)。与一般人群相比，乳糜泻患者患非酒精性脂肪肝的风险更高。超额风险在乳糜泻诊断后第一年最高，但在诊断乳糜泻后持续 15 年。
Nonalcoholic fatty liver disease is a common cause of chronic liver disease. Celiac disease alters intestinal permeability and treatment with a gluten-free diet often causes weight gain, but so far there are few reports of nonalcoholic fatty liver disease in patients with celiac disease. Population-based cohort study. We compared the risk of nonalcoholic fatty liver disease diagnosed from 1997-2009 in individuals with celiac disease (n=26,816) to matched reference individuals (n=130,051). Patients with any liver disease prior to celiac disease were excluded, as were individuals with a lifetime diagnosis of alcohol-related disorder to minimize misclassification of nonalcoholic fatty liver disease. Cox regression estimated hazard ratios for nonalcoholic fatty liver disease were determined. During 246,559 person-years of follow-up, 53 individuals with celiac disease had a diagnosis of nonalcoholic fatty liver disease (21/100,000 person-years). In comparison, we identified 85 reference individuals diagnosed with nonalcoholic fatty liver disease during 1,488,413 person-years (6/100,000 person-years). This corresponded to a hazard ratio of 2.8 (95%CI=2.0-3.8), with the highest risk estimates seen in children (HR=4.6; 95%CI=2.3-9.1). The risk increase in the first year after celiac disease diagnosis was 13.3 (95%CI=3.5-50.3) but remained significantly elevated even beyond 15 years after the diagnosis of celiac disease (HR=2.5; 95% CI 1.0-5.9). Individuals with celiac disease are at increased risk of nonalcoholic fatty liver disease compared to the general population. Excess risks were highest in the first year after celiac disease diagnosis, but persisted through 15 years beyond diagnosis with celiac disease.
登录
查看更多内容
影响因子：
4.3
作者：
Norsa, Lorenzo;Shamir, Raanan;Giovannini, Marcello
通讯作者：
Giovannini, Marcello
影响因子：
64.8
作者：
MOHLER, KM;SLEATH, PR;BLACK, RA
通讯作者：
BLACK, RA
影响因子：
1.3
作者：
Kaesch, J. K.;Bechmann, L. P.;Canbay, A.
通讯作者：
Canbay, A.
影响因子：
7.6
作者：
Ludvigsson, J. F.;Sanders, D. S.;Wahlstrom, J.
通讯作者：
Wahlstrom, J.
影响因子：
2.9
作者：
Cheng, Jianfeng;Brar, Pardeep S.;Green, Peter H. R.
通讯作者：
Green, Peter H. R.