Expression of epidermal growth factor-like domain 7 is increased by transcatheter arterial embolization of liver tumors.
Expression of epidermal growth factor-like domain 7 is increased by transcatheter arterial embolization of liver tumors.
复制标题
肝肿瘤经导管动脉栓塞可增加表皮生长因子样结构域 7 的表达。
DOI：
10.7314/apjcp.2015.16.3.1191
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Chao Yang
中科院分区：
文献类型：
--
作者：
Xiao-Chun Shen;Yu Yin;Peng Du;Chao Yang
BACKGROUND
Epidermal growth factor-like domain multiple 7 (EGFL7), recently identified as a secreted protein regulated by oxygen exposure, plays a critical role in promoting metastasis of hepatocellular carcinoma (HCC). Transcatheter arterial embolization (TAE) is widely used for treatment of HCC, resulting in hypoxia in tumors and surrounding liver tissues. Accordingly, we proposed the hypothesis that there could be a relationship between expression of EGFL7 and response to TAE.
MATERIALS AND METHODS
We established a rabbit VX2 liver tumor model using percutaneous puncture technique guided by computed tomography. TAE and sham embolization were performed and the results were confirmed by MRI 3 weeks after inoculation. We investigated the EGFL7 expression of the two groups at 6h and 3 days after intervention by means of immunohistochemistry and Western blotting.
RESULTS
Immunohistochemical staining demonstrated that the levels of EGFL7 protein significantly increased in the TAE-treated tumors compared with the control group at 6 hours (P=0.031) and 3 days (P=0.020) after intervention. Meanwhile, the relative EGFL7 protein detected in TAE group also up-regulated compared with the control group at 6 hours (P=0.020) and 3 days (P=0.024) after intervention.
CONCLUSIONS
This study reveals an increase of EGFL7 expression in rabbit VX2 liver tumors after TAE. The role of EGFL7 in HCC, especially its biological behavior after TAE, needs further investigation.
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影响因子：
5.5
作者：
W.-G. Liu;W. Gu;Y-B Zhou;H-F Tang;M-J Li;W. Ma
通讯作者：
W.-G. Liu;W. Gu;Y-B Zhou;H-F Tang;M-J Li;W. Ma
影响因子：
5.1
作者：
Marrero, Jorge A;Pelletier, Shawn
通讯作者：
Pelletier, Shawn
影响因子：
1.5
作者：
Gilles, HoChong;Garbutt, Tonora;Landrum, Jasmine
通讯作者：
Landrum, Jasmine
影响因子：
81.5
作者：
Llovet, Josep M.;Zucman-Rossi, Jessica;Gores, Gregory
通讯作者：
Gores, Gregory
影响因子：
--
作者：
Dai, Xin-Zheng;Yin, Hai-Tao;Li, Xiang-Cheng
通讯作者：
Li, Xiang-Cheng