Self-reported major mobility disability and mortality among cancer survivors.
Self-reported major mobility disability and mortality among cancer survivors.
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DOI：
10.1016/j.jgo.2018.03.004
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发表时间：
2018-09
影响因子：
3
通讯作者：
Harhay MN
中科院分区：
文献类型：
--
作者：
Brown JC;Harhay MO;Harhay MN
量化自我报告的主要活动障碍（SR-MMD）的患病率及其与全国代表性癌症幸存者样本死亡率的相关性。这项研究包括参与1999 - 2010年国家健康和营养检查调查的癌症病史患者。SR-MMD被定义为自我报告的行走困难或无法行走四分之一英里。截至2011年12月15日的生命状态由美国国家卫生统计中心确定。多变量校正的考克斯回归模型用于量化SR-MMD和死亡率之间的风险比（HR）和95%置信区间（CI）。该研究包括1，458名癌症幸存者，平均年龄为67.1岁。基线时，201例（13.7%）参与者患有SR-MMD。在平均4.7年的随访期间，434名（29.8%）参与者死亡。SR-MMD与全因死亡率[风险比（HR）：2.15（95%置信区间（CI）：1.56 - 2.97）; P<0.001]和癌症特异性死亡率[HR：2.49（95% CI：1.53 - 4.07）; P<0.001]的风险升高独立相关。SR-MMD和全因死亡率之间的关联并不受年龄、性别、癌症诊断后的时间、体重指数或共病健康状况的影响。SR-MMD是一种容易确定的身体功能指标，与癌症幸存者的死亡风险较高相关。综合身体功能的措施可能有助于指导临床决策，并改善这一人群的长期预后。应在该人群中评价预防SR-MDD发展的干预措施，如体力活动。
To quantify the prevalence of self-reported major mobility disability (SR-MMD) and its association with mortality in a nationally-representative sample of cancer survivors. This study included patients with a history of cancer who participated in the National Health and Nutrition Examination Survey 1999─2010. SR-MMD was defined as self-reported difficulty or inability to walk a quarter of a mile. Vital status through December 15, 2011 was ascertained from the United States National Center for Health Statistics. Multivariable-adjusted Cox regression models were used to quantify the hazard ratio (HR) and 95% confidence interval (CI) between SR-MMD and mortality. The study included 1,458 cancer survivors who averaged 67.1 years of age. At baseline, 201 (13.7%) participants had SR-MMD. During a median follow-up of 4.7 years, 434 (29.8%) participants died. SR-MMD was independently associated with a higher risk of all-cause mortality [Hazard Ratio (HR): 2.15 (95% Confidence Interval (CI): 1.56 2.97); P<0.001] and cancer-specific mortality [HR: 2.49 (95% CI: 1.53 4.07); P<0.001]. The association between SR-MMD and all-cause mortality was not modified by age, sex, time since cancer diagnosis, body mass index, or comorbid health conditions. SR-MMD is an easily ascertainable metric of physical function that is associated with a higher risk of mortality among cancer survivors. Integrating measures of physical function may help to guide clinical decision-making and improve long-term prognostication in this population. Interventions that prevent the development of SR-MDD, such as physical activity, should be evaluated in this population.
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影响因子：
5
作者：
Lochner, Kimberly;Hummer, Robert A.;Cox, Christine
通讯作者：
Cox, Christine
影响因子：
20.8
作者：
BUCHNER, DM;BERESFORD, SAA;WAGNER, EH
通讯作者：
WAGNER, EH
影响因子：
8.8
作者：
Brown, J. C.;Harhay, M. O.;Harhay, M. N.
通讯作者：
Harhay, M. N.
影响因子：
45.3
作者：
Demark-Wahnefried, Wendy;Morey, Miriam C.;Cohen, Harvey J.
通讯作者：
Cohen, Harvey J.
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM