Assessment of relationships between site-specific variables.

Assessment of relationships between site-specific variables.
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评估特定地点变量之间的关系。

DOI:
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发表时间:
1990
期刊:
The Journal of Periodontology
影响因子:
--
通讯作者:
T. Derouen
T. Derouen
中科院分区:
--
文献类型:
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作者:
P. Hujoel;W. Loesche;T. Derouen

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特定位点变量之间的关系的评估一直是一个有争议的问题,因为在个人的牙周网站可以作为独立的观察统计模型的索赔。这种方法的一个问题是计算的I型和II型错误率的不可靠性。另一个问题是,这种不适当的分析可能会妨碍正确评估特定地点变量之间的因果关系。宿主因子可作为效应调节因子,调节位点特异性效应的大小,和/或宿主因子可通过将患者效应叠加在研究的位点特异性效应上,作为混杂因素,导致偏倚。因此,疾病进展的位点特异性生物学机制可能被误解。地点可以作为分析的实验单位,但不应忽视产生地点特定数据的抽样设计。
The assessment of relationships between site-specific variables has been a matter of controversy because of the claim that periodontal sites within individuals can be used as independent observations in statistical models. One problem with this approach is the unreliability of the calculated Type I and Type II error rates. Another problem is that such inappropriate analysis may prohibit a correct assessment of causal relationships between site-specific variables. The host-factor can act as an effect modifier and modulate the magnitude of the site-specific effects and/or the host-factor can act as a confounder by superimposing a patient-effect on the studied site-specific effects leading to bias. As a result, site-specific biological mechanisms of disease progression may be misinterpreted. Sites can be used as the experimental unit of analysis, but the sampling design from which the site-specific data originated should not be ignored.
牙周炎的临床测量。
DOI: 10.1111/j.1600-051x.1986.tb01489.x
发表时间: 1986
影响因子: 6.7
作者:
Goodson,JM
通讯作者: Goodson,JM
DOI: 10.1111/j.1600-051x.1987.tb01520.x
发表时间: 1987
影响因子: 6.7
作者:
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通讯作者: Dzink,JL
DOI: 10.1111/j.1600-051x.1988.tb01594.x
发表时间: 1988
影响因子: 6.7
作者:
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通讯作者: Goodson,JM