Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis.
Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis.
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DOI：
10.1371/journal.pone.0198223
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Zha L
中科院分区：
文献类型：
--
作者：
Gu L;Wang Z;Zuo J;Li H;Zha L
核因子κ B（NF-κB）是一种重要的核转录因子，与多种肿瘤的预后密切相关。但NF-κB在非小细胞肺癌（NSCLC）中的临床应用价值仍存在争议。因此，本荟萃分析的目的是基于已发表的文献，准确评估NF-κB表达与NSCLC患者生存预后的关系。对PubMed、EMBASE和Web of Science数据库进行了系统性检索，以查找潜在文章。我们的荟萃分析共纳入了来自7项比较NF-κB表达水平对NSCLC预后意义的合格研究的1159例患者。采用I2统计量和P值评价异质性。分析结果以风险比（HR）或比值比（OR）和95%置信区间（95% CI）表示。基于NSCLC患者的种族和癌细胞内NF-kB细胞定位进行亚组分析，以说明潜在的差异。当I2>50%且P<0.05时，认为异质性显著，采用随机效应模型。NF-κB的高表达与NSCLC患者的总生存期（OS）缩短相关（HR = 2.78，95%CI = 1.51-5.12，P = 0.001）。NF-κB表达与肿瘤分期密切相关（HR = 0.32，95%CI = 0.18-0.57，P<0.0001），淋巴结转移非小细胞肺癌患者5年生存率（OR = 1.83，95%CI = 1.02-3.31，P = 0.04）。NF-κB表达可能是NSCLC患者预后不良的潜在指标。
Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity. The results of analysis were presented as hazard ratio (HR) or odds ratios (OR) with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients and NF-kB cellular localization within cancer cells were conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2>50% and P<0.05, and random-effects model was used. The combined results indicated that higher NF-κB expression was associated with shorter overall survival (OS) of NSCLC patients (HR = 2.78, 95% CI = 1.51–5.12, P = 0.001). Moreover, NF-κB expression was closely associated with tumor stage (HR = 0.32, 95% CI = 0.18–0.57, P<0.0001), lymph node metastasis (HR = 0.56, 95% CI = 0.38–0.83, P = 0.004) and 5-year OS for NSCLC patients (OR = 1.83, 95% CI = 1.02–3.31, P = 0.04). We conclude that NF-κB expression may be a potential unfavorable prognostic marker for NSCLC patients.
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影响因子：
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作者：
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发表时间：
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