Exosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: critical analysis of evidence and potential role in clinical practice.
Exosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: critical analysis of evidence and potential role in clinical practice.
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DOI：
10.18632/oncotarget.7638
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发表时间：
2016-05-10
期刊：
影响因子：
--
通讯作者：
Rolfo C
中科院分区：
文献类型：
--
作者：
Taverna S;Giallombardo M;Gil-Bazo I;Carreca AP;Castiglia M;Chacártegui J;Araujo A;Alessandro R;Pauwels P;Peeters M;Rolfo C
外泌体是内溶酶体来源的纳米大小的囊泡，在生理和病理条件下由几种细胞型释放。肿瘤来源的外泌体与肿瘤微环境的其他细胞相互作用，调节肿瘤进展、血管生成开关、转移和免疫逃逸。最近，细胞外囊泡被提出作为癌症患者疾病监测和预后的优良生物标志物。非小细胞肺癌（NSCLC）由于检测延迟，5年生存率很低。大多数患者被诊断为晚期疾病。外泌体可能是有前途的有益工具，作为NSCLC情况下的生物标志物候选物，因为它们含有蛋白质和miRNA。该手稿中报告的临床病例是一个概念证明，揭示了NSCLC外泌体和分选的miRNA可能在不久的将来构成新的生物标志物。本文综述了外泌体在非小细胞肺癌中的作用，重点阐述了外泌体microRNA在肺癌诊断和预后中的重要性。
Exosomes are nano-sized vesicles of endolysosomal origin, released by several cytotypes in physiological and pathological conditions. Tumor derived exosomes, interacting with other cells of the tumor microenvironment, modulate tumor progression, angiogenic switch, metastasis, and immune escape. Recently, extracellular vesicles were proposed as excellent biomarkers for disease monitoring and prognosis in cancer patients. Non-small cell lung cancer (NSCLC) has a poor 5-year survival rate due to the delay in the detection of the disease. The majority of patients are diagnosed in an advanced disease stage. Exosomes might be promising beneficial tools as biomarker candidates in the scenario of NSCLC, since they contain both, proteins and miRNAs. The clinical case reported in this manuscript is a proof of concept revealing that NSCLC exosomes and sorted miRNAs might constitute, in a near future, novel biomarkers. This review summarizes the role of exosomes in NSCLC, focusing on the importance of exosomal microRNAs in lung cancer diagnosis and prognosis.
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