Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso.
Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso.
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DOI：
10.1002/hep4.1595
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发表时间：
2020-12
影响因子：
5.1
通讯作者：
Roberts LR
中科院分区：
文献类型：
--
作者：
Wongjarupong N;Yonli AT;Nagalo BM;Djigma FW;Somda SK;Hassan MA;Mohamed EA;Sorgho AP;Compaore TR;Soubeiga ST;Kiendrebeogo I;Sanou M;Diarra B;Yang HI;Chen CJ;Ouattara AK;Zohoncon TM;Martinson JJ;Buetow K;Chamcheu JC;Antwi SO;Borad MJ;Simpore J;Roberts LR
在西非，乙型肝炎病毒（HBV）基因型E （HBV‐E）占慢性乙型肝炎（CHB）感染的大多数。我们旨在确定与西非HBV - E -诱导的肝细胞癌（HCC）相关的因素。对布基纳法索乙型肝炎表面抗原阳性（HBsAg+）和CHB患者的数据进行了分析。在3885例CHB无HCC患者（CHB HCC -）和59例CHB合并HCC患者（CHB HCC+）中检测HBV病毒载量和乙型肝炎e抗原（HBeAg）状态。对364例CHB HCC -和41例CHB HCC+患者进行HBV基因分型。总体而言，CHB HCC -组中2.5%为HBeAg+，而CHB HCC+组为0%。在364例CHB - HCC患者中，HBV基因型E和C/E的频率分别为70.3%和12.9%。年龄（老年人的比值比[OR]为1.08；95%可信区间[CI]为1.06‐1.10 / 1年）、男性（OR为2.03；95% CI为1.11‐3.69）和HBV病毒血症（OR为1.48；95% CI为1.31‐1.67 / 1 log10 IU/mL）均与HCC诊断相关。与基因型C/E患者相比，基因型E患者的HBeAg患病率较低（6.3%对14.9%），HBV病毒载量较低，肝硬化患病率较高（14.5%对4.8%）。结论：HBV‐E是西非患者中最常见的循环毒株（70.3%）。HCC与年龄较大、男性和高HBV病毒载量有关。预计这些结果将进一步为西非HBV感染的临床管理提供指导。
Hepatitis B virus (HBV) genotype E (HBV‐E) accounts for the majority of chronic hepatitis B (CHB) infections in West Africa. We aimed to determine factors associated with HBV‐E‐induced hepatocellular carcinoma (HCC) in West Africa. Data on patients from Burkina Faso who were hepatitis B surface antigen positive (HBsAg+) and had CHB were analyzed. HBV viral load and hepatitis B e antigen (HBeAg) status were measured in 3,885 individuals with CHB without HCC (CHB HCC−) and 59 individuals with CHB with HCC (CHB HCC+). HBV genotyping was performed for 364 subjects with CHB HCC− and 41 subjects with CHB HCC+. Overall, 2.5% of the CHB HCC− group was HBeAg+ compared with 0% of the CHB HCC+ group. Of the 364 patients who were CHB HCC− with available genotyping, the frequencies of HBV genotypes E and C/E were 70.3% and 12.9%, respectively. Age (odds ratio [OR] for older age, 1.08; 95% confidence interval [CI], 1.06‐1.10 per 1‐year increase in age), male sex (OR, 2.03; 95% CI, 1.11‐3.69), and HBV viremia (OR, 1.48; 95% CI, 1.31‐1.67 per 1 log10 IU/mL) were each associated with HCC diagnosis. Patients with genotype E had a lower HBeAg prevalence (6.3% vs. 14.9%), lower HBV viral load, and higher prevalence of cirrhosis (14.5% vs. 4.8%) than patients with genotype C/E. Conclusion: HBV‐E is the most common circulating strain (70.3%) in West African patients. HCC was associated with older age, male sex, and high HBV viral load. It is expected that these results will further inform guidance on clinical management of HBV infection in West Africa.
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Schlabe S;van Bremen K;Aldabbagh S;Glebe D;Bremer CM;Marsen T;Mellin W;Cristanziano VD;Eis-Hübinger AM;Spengler U
通讯作者：
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