The Initiation of DNA Replication in Eukaryotes
The Initiation of DNA Replication in Eukaryotes
复制标题
真核生物中 DNA 复制的起始
DOI：
10.1007/978-3-319-24696-3_17
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
De Piccoli G
中科院分区：
文献类型：
--
作者：
De Piccoli G
通过附着泛素或泛素样蛋白（ubitin -like proteins, UBLs）对蛋白质进行翻译后修饰，改变修饰因子的三维结构，影响它们的活性、相互作用和周转。泛素和ubl构成了一个非常通用和灵活的蛋白质修饰系统，并调节细胞生物学的几乎每一个方面。在本章中，我们将重点讨论这些小蛋白修饰剂在DNA复制起始调控中的作用。我们回顾了积累的知识，展示了泛素驱动的蛋白酶体降解如何导致细胞周期中允许DNA复制起始的顺序，非重叠阶段的创建，以及它如何防止S期的再复制。我们还解释了泛素化在DNA损伤反应中抑制DNA复制起始的作用。由于复制因子的调控通常是通过小蛋白修饰剂和磷酸化修饰来执行的，我们还讨论了这两种调节机制之间的重要交叉。最后，我们回顾了目前关于非降解形式的泛素化和Nedd8和SUMO修饰对DNA复制起始的调控的知识。
Posttranslational modification of proteins through attachment of ubiquitin or ubiquitin-like proteins (UBLs) changes the three-dimensional structure of the modified factors and affects their activity, interactions, and turnover. Ubiquitin and UBLs constitute a very versatile and flexible system of protein modification and regulate almost every aspect of cell biology. In this chapter we focus on the role of these small protein modifiers in regulation of DNA replication initiation. We review the accumulated knowledge showing how ubiquitin-driven proteasomal degradation leads to creation of sequential, non-overlapping stages of the cell cycle allowing DNA replication initiation and how it prevents re-replication during S phase. We also explain the role ubiquitylation plays in the inhibition of DNA replication initiation in response to DNA damage. As the regulation of replication factors is often executed through modifications with both small protein modifiers and phosphorylation we also discuss the important crossovers between these two regulatory mechanisms. Finally, we review our present knowledge of regulation of DNA replication initiation by non-degradative forms of ubiquitylation and modifications with Nedd8 and SUMO.
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影响因子：
3.7
作者：
S. Tada;J. Blow
通讯作者：
J. Blow
p53 家族的泛素和泛素样修饰。
影响因子：
4.8
作者：
I. Watson;M. Irwin
通讯作者：
M. Irwin
DOI：
10.1098/rstb.2011.0073
发表时间：
2011-12-27
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Diffley JF
通讯作者：
Diffley JF
影响因子：
16
作者：
Rossi, Mario;Duan, Shanshan;Jeong, Yeon-Tae;Horn, Moritz;Saraf, Anita;Florens, Laurence;Washburn, Michael P.;Antebi, Adam;Pagano, Michele
通讯作者：
Pagano, Michele
影响因子：
56.9
作者：
Kim, TK;Ebright, RH;Reinberg, D
通讯作者：
Reinberg, D