A uniformity correction method to reduce scan time for 7T sodium imaging of brain tumors.
A uniformity correction method to reduce scan time for 7T sodium imaging of brain tumors.
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DOI：
10.1111/jon.13041
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发表时间：
2022-11
影响因子：
2.4
通讯作者：
Lin, Alexander Peter
中科院分区：
文献类型：
--
作者：
Kim, Sanghoon;Merugumala, Sai;Lin, Alexander Peter
钠成像显示出巨大的潜力，脑肿瘤的特点。需要强度校正，但额外的扫描时间是昂贵的。最近的发展可以将时间减半，但在正常大脑中进行了优化，可能不适用于脑肿瘤成像。我们的目标是开发一种针对脑肿瘤患者优化的钠成像的个性化均匀性校正，以减少扫描时间，但为临床实践提供高分辨率图像。使用2 mm、4 mm和6 mm等立方体素分辨率鸟笼线圈图像计算健康受试者（n=3）的2 mm等立方体素个体灵敏度图。比较切割剖面以确定最佳方法。此外，还开发了一种3D体模，用于在健康受试者（n=3）和肿瘤患者（n=3）中测试广义均匀性校正方法。切割剖面显示，2 mm和4 mm鸟笼图像校正结果之间的平均相关系数分别为r = 0.9937，2 mm和6 mm鸟笼图像的平均相关系数分别为r = 0.9876。个体标测图校正与体模标测图校正之间的相关性结果为r = 0.9817。4 mm鸟笼线圈图像为两者提供了最佳方法，作为节省时间效果和图像质量之间的折衷。该方法允许在12分钟内进行2mm等立方体素分辨率的临床钠扫描。我们还提供了预扫描体模灵敏度图结果，其设计涵盖所有患者头部尺寸。这一办法为时间较紧的案件提供了另一种解决办法。
Sodium imaging shows great potential for the characterization of brain tumors. Intensity correction is required but the additional scan time is costly. Recent developments can halve the time but were optimized in normal brains and may not be applicable in brain tumor imaging. We aim to develop an individualized uniformity correction for sodium imaging optimized for brain tumor patients that reduces scan time but provides high-resolution images for clinical practice. Two mm, 4 mm, and 6 mm iso-cubic voxel resolution birdcage coil images were used to calculate the 2 mm iso-cubic voxel individual sensitivity maps in healthy subjects (n=3). Cut profiles were compared to determine the optimal approach. In addition, a 3D phantom was developed to test a generalized uniformity correction approach in both healthy subjects (n=3) and tumor patients (n=3). The cut profiles showed that the average correlation coefficient between 2 mm and 4 mm birdcage image correction results was r = 0.9937, and r = 0.9876 for 2 mm and 6 mm birdcage images, respectively. The correlation result between individual map correction and phantom map correction was r = 0.9817. The 4 mm birdcage coil image provided the optimal approach for both as a compromise between the time-savings effect and image quality. This method allows for a 2mm iso-cubic voxel resolution clinical sodium scan within 12 minutes. We also presented pre-scanned phantom sensitivity map results, which were designed to cover all patient head sizes. This approach provides an alternative solution in more time-sensitive cases.
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DOI：
10.1016/j.nicl.2020.102427
发表时间：
2020
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Regnery S;Behl NGR;Platt T;Weinfurtner N;Windisch P;Deike-Hofmann K;Sahm F;Bendszus M;Debus J;Ladd ME;Schlemmer HP;Rieken S;Adeberg S;Paech D
通讯作者：
Paech D
影响因子：
1.3
作者：
HILAL, SK;MAUDSLEY, AA;MUN, SK
通讯作者：
MUN, SK
影响因子：
2
作者：
Lachner, Sebastian;Ruck, Laurent;Nagel, Armin M.
通讯作者：
Nagel, Armin M.
影响因子：
3.3
作者：
Murakami, JW;Hayes, CE;Weinberger, E
通讯作者：
Weinberger, E
影响因子：
3.3
作者：
Bydder, M;Larkman, DJ;Hajnal, JV
通讯作者：
Hajnal, JV