Emotional recognition training modifies neural response to emotional faces but does not improve mood in healthy volunteers with high levels of depressive symptoms
Emotional recognition training modifies neural response to emotional faces but does not improve mood in healthy volunteers with high levels of depressive symptoms
复制标题
情绪识别训练可以改变对情绪面孔的神经反应，但不能改善患有严重抑郁症状的健康志愿者的情绪
DOI：
10.1101/335042
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Penton-Voak I
中科院分区：
文献类型：
--
作者：
Penton-Voak I
BackgroundThere是需要新的，有效的和可扩展的治疗抑郁症，和发展的新形式的认知偏差修正（CBM）的负面情绪处理偏见已被建议作为可能的干预措施，以满足这一需求。有高度抑郁症状的志愿者（贝克抑郁量表ii（BDI-ii）> 14）完成了简短的情绪识别训练课程（一种使用面部的CBM的新形式）或假训练。在研究1（N = 36）中，参与者完成了训练后的情绪识别任务，同时进行功能性磁共振成像，以调查CBM的神经相关性。在研究2（N = 190）中，情绪的措施进行了评估后的培训，并在2周和6周的follow-up.ResultsIn这两项研究中，CBM导致在情绪识别偏差，这（在研究2）持续6周后，培训结束的初始变化。在研究1中，CBM导致了对快乐面孔的神经激活增加，这种效应是由内侧前额叶皮层和双侧杏仁核的神经活动增加驱动的。在研究2中，CBM并没有导致减少抑郁症状的BDI-II，或相关措施的情绪，动机和持久性，或抑郁的解释偏见在任何2或6周following.ConclusionsCBM的情绪识别有影响神经活动，在某些方面是相似的诱导选择性5-羟色胺再摄取抑制剂（SSRI）管理（研究1），但我们没有发现证据表明这对情绪低落的非临床志愿者的类似样本中的自我报告情绪有任何后期影响（研究2）。
BackgroundThere is demand for new, effective and scalable treatments for depression, and development of new forms of cognitive bias modification (CBM) of negative emotional processing biases has been suggested as possible interventions to meet this need.MethodsWe report two double blind RCTs, in which volunteers with high levels of depressive symptoms (Beck Depression Inventory ii (BDI-ii) > 14) completed a brief course of emotion recognition training (a novel form of CBM using faces) or sham training. In Study 1 (N = 36), participants completed a post-training emotion recognition task whilst undergoing functional magnetic resonance imaging to investigate neural correlates of CBM. In Study 2 (N = 190), measures of mood were assessed post-training, and at 2-week and 6-week follow-up.ResultsIn both studies, CBM resulted in an initial change in emotion recognition bias, which (in Study 2) persisted for 6 weeks after the end of training. In Study 1, CBM resulted in increases neural activation to happy faces, with this effect driven by an increase in neural activity in the medial prefrontal cortex and bilateral amygdala. In Study 2, CBM did not lead to a reduction in depressive symptoms on the BDI-ii, or on related measures of mood, motivation and persistence, or depressive interpretation bias at either 2 or 6-week follow-ups.ConclusionsCBM of emotion recognition has effects on neural activity that are similar in some respects to those induced by Selective Serotonin Reuptake Inhibitors (SSRI) administration (Study 1), but we find no evidence that this had any later effect on self-reported mood in an analogue sample of non-clinical volunteers with low mood (Study 2).
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影响因子：
10.5
作者：
Harmer, Catherine J.;Goodwin, Guy M.;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
7.2
作者：
Penton-Voak, Ian S.;Munafo, Marcus R.;Looi, Chung Yen
通讯作者：
Looi, Chung Yen
影响因子：
4.1
作者：
Pictet, Arnaud;Coughtrey, Anna E.;Mathews, Andrew;Holmes, Emily A.
通讯作者：
Holmes, Emily A.
影响因子：
5.9
作者：
BECK, AT;BROWN, G;STEER, RA
通讯作者：
STEER, RA
影响因子：
10.6
作者：
Harmer, CJ;Mackay, CE;Goodwin, GM
通讯作者：
Goodwin, GM