Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants.
Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants.
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DOI：
10.1002/art.30381
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发表时间：
2011-07
影响因子：
--
通讯作者：
Greenspan, John S.
中科院分区：
文献类型：
--
作者：
Daniels, Troy E.;Cox, Darren;Shiboski, Caroline H.;Schiodt, Morten;Wu, Ava;Lanfranchi, Hector;Umehara, Hisanori;Zhao, Yan;Challacombe, Stephen;Lam, Mi Y.;De Souza, Yvonne;Schiodt, Julie;Holm, Helena;Bisio, Patricia A. M.;Gandolfo, Mariana S.;Sawaki, Toshioki;Li, Mengtao;Zhang, Wen;Varghese-Jacob, Beni;Ibsen, Per;Keszler, Alicia;Kurose, Nozomu;Nojima, Takayuki;Odell, Edward;Criswell, Lindsey A.;Jordan, Richard;Greenspan, John S.
干燥综合征国际合作临床联盟 (SICCA) 是一个由美国国立卫生研究院 (NIH) 资助的持续注册登记机构，其队列范围从具有可能的干燥综合征 (SS) 症状的患者到患有明显疾病的患者。使用该数据库，我们检查了唇唾液腺 (LSG) 组织病理学与 SS 其他表型特征之间的关联。 SICCA 参与者的 LSG 活检标本接受了方案指导的组织病理学评估。在 1726 份表现出任何唾液腺炎模式的 LSG 标本中，我们将活检诊断与同时进行的唾液、眼部和血清学评估进行了比较。 LSG 标本中 61% 患有局灶性淋巴细胞唾液腺炎（FLS；其中 66% 的病灶评分 [FS] ≥ 1/4 mm2），38% 患有非特异性或硬化性慢性唾液腺炎 (NS/SCS)。 FS ≥ 1 与血清抗 SS-A/-B、类风湿因子和 SS 眼部成分阳性密切相关，但与口干或眼干症状无关。抗 SS-A/-B 阳性患者 FS ≥ 1 的可能性 (95% CI: 7.4; 11.9) 比 FS <1 或其他模式高 9 倍，而未刺激总唾液流量 < 0.1 ml/min 的患者 FS ≥ 1 (95% CI: 1.7; 2.8) 的可能性仅比 FS <1 或其他模式高 2 倍，同时控制其他模式SS的表型特征。在确定 FS 之前，区分 FLS 和 NS/SCS 对于评估 LSG 活检至关重要。与 FS < 1 的 FLS 或 NS/SCS 相比，FS ≥ 1 每 4 mm2 的 FLS 诊断与 SS 的眼部和血清学成分密切相关，并反映 SS 自身免疫。
The Sjögren’s International Collaborative Clinical Alliance (SICCA) is an ongoing NIH-funded registry whose cohort ranges from those with symptoms of possible Sjögren’s syndrome (SS) to those with obvious disease. Using this database we examined associations between labial salivary gland (LSG) histopathology and other phenotypic features of SS. LSG biopsy specimens from SICCA participants underwent protocol-directed histopathological assessments. Among 1726 LSG specimens exhibiting any pattern of sialadenitis, we compared biopsy diagnoses against concurrent salivary, ocular and serological assessments. LSG specimens included 61% with focal lymphocytic sialadenitis, (FLS; 66% of which had focus scores [FS] ≥ 1 per 4 mm2) and 38% with non-specific or sclerosing chronic sialadenitis (NS/SCS). FS ≥ 1 was strongly associated with positive serum anti-SS-A/-B, rheumatoid factor and the ocular component of SS, but not with symptoms of dry mouth or eyes. Those with positive anti-SS-A/-B were 9 times more likely to have a FS ≥ 1 (95% CI: 7.4; 11.9) than FS<1 or another pattern, while those with unstimulated whole salivary flow < 0.1 ml/min were only 2 times more likely to have a FS ≥ 1 (95% CI:1.7; 2.8) than FS<1 or another pattern, while controlling for other phenotypic features of SS. Distinguishing FLS from NS/SCS is essential in assessing LSG biopsies, before determining FS. A diagnosis of FLS with FS ≥ 1 per 4 mm2, as compared to FLS with FS< 1 or with NS/SCS, was strongly associated with the ocular and serological components of SS and reflects SS autoimmunity.
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影响因子：
4.2
作者：
Whitcher, John P.;Shiboski, Caroline H.;Shiboski, Stephen C.;Maria Heidenreich, Ana;Kitagawa, Kazuko;Zhang, Shunhua;Hamann, Steffen;Larkin, Genevieve;McNamara, Nancy A.;Greenspan, John S.;Daniels, Troy E.
通讯作者：
Daniels, Troy E.
影响因子：
--
作者：
FOX, RI;ROBINSON, CA;HOWELL, FV
通讯作者：
HOWELL, FV
DOI：
10.1016/0030-4220(74)90417-4
发表时间：
1974-01-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
GREENSPAN, JS;DANIELS, TE;SYLVESTER, RA
通讯作者：
SYLVESTER, RA
影响因子：
27.4
作者：
Vitali, C;Bombardieri, S;Nelson, M
通讯作者：
Nelson, M
影响因子：
--
作者：
Daniels, Troy E.;Criswell, Lindsey A.;Shiboski, Caroline;Shiboski, Stephen;Lanfranchi, Hector;Dong, Yi;Schiodt, Morten;Umehara, Hisanori;Sugai, Susumu;Challacombe, Stephen;Greenspan, John S.
通讯作者：
Greenspan, John S.