A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry.
A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry.
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DOI：
10.1016/j.ajo.2009.09.013
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发表时间：
2010-03
影响因子：
4.2
通讯作者：
Daniels, Troy E.
中科院分区：
文献类型：
--
作者：
Whitcher, John P.;Shiboski, Caroline H.;Shiboski, Stephen C.;Maria Heidenreich, Ana;Kitagawa, Kazuko;Zhang, Shunhua;Hamann, Steffen;Larkin, Genevieve;McNamara, Nancy A.;Greenspan, John S.;Daniels, Troy E.
目的描述、应用和测试一种新的眼部分级系统，用于使用丽丝胺绿色和荧光素评估干燥性角结膜炎（KCS）。目的前瞻性、观察性、方法：美国国立卫生研究院资助的干燥综合征国际登记研究（称为舍格伦国际合作临床联盟[SICCA]）正在制定舍格伦综合征（SS）的标准化分类标准并正在为未来的研究建立一个生物标本库。8名SICCA眼科医生开发了一种新的定量眼部分级系统（SICCA眼染色评分[OSS]），我们分析了SICCA队列中OSS的分布及其与SS其他表型特征的相关性。SICCA队列包括从可能的早期SS到晚期疾病的参与者。程序包括顺序的非麻醉Schirmer试验，泪膜破裂时间，眼表染色，以及在裂隙灯下的外眼检查。使用统计分析和比例文氏图，我们研究了异常OSS（≥3）与SS其他特征之间的相互关系（唇唾液腺[LSG]活检伴局灶性淋巴细胞性涎腺炎且病灶评分>1阳性抗SS A抗体、抗SS B抗体或两者）。通过对1208名参与者进行TSAm，我们发现异常OSS、阳性血清学结果、阳性LSG病灶评分（P < .0001）。这3个措施的重叠关系的分析定义了一个大组的参与者谁KCS没有其他组件的SS，代表一个临床实体不同的KCS与SS. CONCLUSIONSSThis新的方法来评估KCS将成为手段，用于诊断眼组件的SS在未来的分类标准。我们发现两种形式的KCS，其原因可能不同。
PURPOSETo describe, apply, and test a new ocular grading system for assessing keratoconjunctivitis sicca (KCS) using lissamine green and fluorescein.DESIGNProspective, observational, multicenter cohort study.METHODSThe National Institutes of Health-funded Sjögren's Syndrome International Registry (called Sjögren's International Collaborative Clinical Alliance [SICCA]) is developing standardized classification criteria for Sjögren syndrome (SS) and is creating a biospecimen bank for future research. Eight SICCA ophthalmologists developed a new quantitative ocular grading system (SICCA ocular staining score [OSS]), and we analyzed OSS distribution among the SICCA cohort and its association with other phenotypic characteristics of SS. The SICCA cohort includes participants ranging from possibly early SS to advanced disease. Procedures include sequenced unanesthetized Schirmer test, tear break-up time, ocular surface staining, and external eye examination at the slit lamp. Using statistical analyses and proportional Venn diagrams, we examined interrelationships between abnormal OSS (≥3) and other characteristics of SS (labial salivary gland [LSG] biopsy with focal lymphocytic sialadenitis and focus score >1 positive anti-SS A antibodies, anti-SS B antibodies, or both).RESULTSAmong 1208 participants, we found strong associations between abnormal OSS, positive serologic results, and positive LSG focus scores (P < .0001). Analysis of the overlapping relationships of these 3 measures defined a large group of participants who had KCS without other components of SS, representing a clinical entity distinct from the KCS associated with SS.CONCLUSIONSThis new method for assessing KCS will become the means for diagnosing the ocular component of SS in future classification criteria. We find 2 forms of KCS whose causes may differ.
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影响因子：
3.9
作者：
Versura, P.;Frigato, M.;Campos, E. C.
通讯作者：
Campos, E. C.
影响因子：
--
作者：
Daniels, Troy E.;Criswell, Lindsey A.;Shiboski, Caroline;Shiboski, Stephen;Lanfranchi, Hector;Dong, Yi;Schiodt, Morten;Umehara, Hisanori;Sugai, Susumu;Challacombe, Stephen;Greenspan, John S.
通讯作者：
Greenspan, John S.
影响因子：
13.7
作者：
Manning, FJ;Wehrly, SR;Foulks, GN
通讯作者：
Foulks, GN
影响因子：
--
作者：
Whitcher, JP;Gritz, DC;Daniels, TE
通讯作者：
Daniels, TE
影响因子：
2.8
作者：
Bron, AJ;Evans, VE;Smith, JA
通讯作者：
Smith, JA