Disrupted correlation between low frequency power and connectivity strength of resting state brain networks in schizophrenia.
Disrupted correlation between low frequency power and connectivity strength of resting state brain networks in schizophrenia.
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DOI：
10.1016/j.schres.2012.11.001
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发表时间：
2013-01
影响因子：
4.5
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
Yu Q;Sui J;Liu J;Plis SM;Kiehl KA;Pearlson G;Calhoun VD
改变的大脑连接已经成为精神分裂症的一个核心特征。精神分裂症患者静息态脑网络的低频振荡和连接强度（CS）发生改变。然而，这两种措施之间的关系尚未得到研究。这样的工作可能有助于理解健康对照（HC）和SZ中所谓的“富人俱乐部”组织（即，高CS节点之间的连接比人脑中CS较低的节点更密集）。在这里，我们提出了一项研究的HC和SZ检查低频振荡和CS的第一次分解静息状态的功能磁共振成像（R-fMRI）数据到独立的组件（IC）使用组独立成分分析（伊卡）和计算的低频功率比（LFPR）的每个伊卡的时间过程。基于伊卡时间过程之间的相关性构建由IC组成的加权脑图。然后检查脑图中每个节点的阳性CS和阴性CS。评估LFPR与CS之间的相关性以及组平均脑图的“富人俱乐部”系数。结果表明，一些IC的LFPR在SZ中比在HC中低。此外，LFPR与HC中的CS阳性相关，但在SZ中的程度较低。HC显示出更高的标准化丰富的俱乐部参数比SZ。这一发现为精神分裂症患者紊乱的内在脑图提供了新的见解。
Altered brain connectivity has emerged as a central feature of schizophrenia. Low frequency oscillations and connectivity strength (CS) of resting state brain networks are altered in patients with schizophrenia (SZs). However, the relationship between these two measures has not yet been studied. Such work may be helpful in understanding the so-called “rich club” organization (i.e. high-CS nodes are more densely connected among themselves than are nodes of a lower CS in the human brain) in healthy controls (HCs) and SZs. Here we present a study of HCs and SZs examining low frequency oscillations and CS by first decomposing resting state fMRI (R-fMRI) data into independent components (ICs) using group independent component analysis (ICA) and computing the low frequency power ratio (LFPR) of each ICA time course. Weighted brain graphs consisting of ICs were built based on correlations between ICA time courses. Positive CS and negative CS of each node in the brain graphs were then examined. The correlations between LFPR and CSs as well as “rich club” coefficients of group mean brain graphs were assessed. Results demonstrate that the LFPR of some ICs were lower in SZs compared to HCs. In addition, LFPR was correlated with positive CS in HCs, but to a lesser extent in SZs. HCs showed higher normalized rich club parameter than SZs. The findings provide new insight into disordered intrinsic brain graphs in schizophrenia.
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影响因子：
5.7
作者：
Bassett, Danielle S.;Nelson, Brent G.;Mueller, Bryon A.;Camchong, Jazmin;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
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通讯作者：
Kiviniemi, Vesa
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作者：
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通讯作者：
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