Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence.
Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence.
复制标题
纳曲酮治疗会导致抑郁症吗？
DOI：
--
复制
发表时间：
2006
影响因子：
4.3
通讯作者：
B. Lawford
中科院分区：
文献类型：
--
作者：
A. Dean;J. Saunders;Rodger Jones;R. Young;J. Connor;B. Lawford
目的
头痛和抑郁症被认为是阿片类拮抗剂纳洛酮的副作用。我们的目的是评估抑郁症状是否是接受纳洛酮治疗阿片类药物依赖的人群中的临床相关副作用。
方法
我们在澳大利亚布里斯班的皇家布里斯班和妇女医院的酒精和药物服务中心进行了一项随机对照、开放标签试验，比较麻醉下快速阿片类药物解毒和纳洛酮治疗与持续美沙酮维持。研究受试者是因海洛因依赖而接受美沙酮维持治疗并病情稳定、希望转为纳洛酮治疗的患者。贝克抑郁量表，状态-特质焦虑量表和阿片类药物治疗指数分量表的海洛因使用和社会功能的基线和后续评估在1，2，3和6个月。
结果
42名参与者被分配接受纳洛酮治疗，而38名继续美沙酮维持作为对照条件。接受纳洛酮的参与者没有表现出抑郁症状的恶化。在参加所有后续评估的参与者中，与对照组相比，接受纳曲酮的参与者的抑郁症有随着时间的推移而改善的趋势。坚持纳洛酮治疗的参与者比不坚持治疗的参与者表现出更少的抑郁症状。
结论
这些结果表明，抑郁症不需要被认为是纳洛酮治疗的常见不良反应或治疗禁忌症，并且参与或坚持纳洛酮治疗可能与较少的抑郁症状相关。
OBJECTIVE
Dysphoria and depression have been cited as side effects of the opioid antagonist naltrexone. We aimed to assess whether depressive symptoms are a clinically relevant side effect in a population receiving naltrexone as a treatment for opioid dependence.
METHODS
We carried out a randomized controlled, open-label trial comparing rapid opiate detoxification under anesthesia and naltrexone treatment with continued methadone maintenance at the Alcohol and Drug Service, Royal Brisbane and Women's Hospital, Brisbane, Australia. The study subjects were patients stabilized on methadone maintenance treatment for heroin dependence who wished to transfer to naltrexone treatment. The Beck Depression Inventory, State-Trait Anxiety Inventory and Opiate Treatment Index subscales for heroin use and social functioning were used at baseline and follow-up assessments at 1, 2, 3 and 6 months.
RESULTS
Forty-two participants were allocated to receive naltrexone treatment, whereas 38 continued methadone maintenance as the control condition. Participants who received naltrexone did not exhibit worsening of depressive symptoms. In participants attending all follow-up assessments, there was a trend for those receiving naltrexone to exhibit an improvement in depression over time compared with the control group. Participants who were adherent to naltrexone treatment exhibited fewer depressive symptoms than those who were nonadherent.
CONCLUSIONS
These results suggest that depression need not be considered a common adverse effect of naltrexone treatment or a treatment contraindication and that engaging with or adhering to naltrexone treatment may be associated with fewer depressive symptoms.
纳曲酮治疗酒精中毒背景下抑郁症的发生和治疗。
DOI：
10.1176/ajp.156.8.1258
发表时间：
1999
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Farren,CK;O'Malley,SS
通讯作者：
O'Malley,SS
可乐定-纳曲酮快速解毒对阿片类药物滥用者的临床实用性。
DOI：
10.1111/j.1360-0443.1988.tb02576.x
发表时间：
1988
期刊：
British journal of addiction
影响因子：
--
作者：
Vining,E;Kosten,TR;Kleber,HD
通讯作者：
Kleber,HD
影响因子：
3.9
作者：
CHILDRESS, AR;EHRMAN, R;OBRIEN, CP
通讯作者：
OBRIEN, CP