Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells.
Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells.
复制标题
DOI：
10.1084/jem.190.10.1527
复制
发表时间：
1999-11-15
期刊：
影响因子：
--
通讯作者：
Veillette A
中科院分区：
文献类型：
--
作者：
Cao MY;Davidson D;Yu J;Latour S;Veillette A
我们发现了一种新的含有白细胞蛋白76 kD （SLP-76）的Src同源2结构域相关分子，我们将其命名为Clnk（细胞因子依赖性造血细胞连接体）。与SLP-76和B细胞连接蛋白（Blnk）不同，Clnk在给定的造血细胞谱系中不均匀表达。尽管它可以在几种细胞类型中检测到，包括T细胞、自然杀伤细胞和肥大细胞，但它的表达似乎严格依赖于持续暴露于白细胞介素(IL)-2和IL-3等细胞因子。Clnk参与免疫受体信号传导的观点得到了强有力的支持，因为在对免疫受体刺激的反应中，Clnk可诱导与至少一种酪氨酸磷酸化多肽（p92）相关。此外，Clnk的短暂表达导致T细胞系中免疫受体介导的信号事件增加。综上所述，这些结果表明Clnk是SLP-76家族的一个新成员，在细胞因子刺激的造血细胞中选择性表达。此外，他们认为Clnk可能参与细胞因子受体和免疫受体信号传导之间的串扰机制。
We have identified a novel Src homology 2 domain–containing leukocyte protein of 76 kD (SLP-76)–related molecule which we have termed Clnk (for cytokine-dependent hemopoietic cell linker). Unlike its relatives SLP-76 and B cell linker protein (Blnk), Clnk is not expressed uniformly within a given hemopoietic cell lineage. Even though it can be detected in several cell types, including T cells, natural killer cells, and mast cells, its expression seems to be strictly dependent on sustained exposure to cytokines such as interleukin (IL)-2 and IL-3. Strong support for the notion that Clnk is involved in immunoreceptor signaling was provided by the observation that it inducibly associated with at least one tyrosine-phosphorylated polypeptide (p92) in response to immunoreceptor stimulation. Moreover, transient expression of Clnk caused an increase in immunoreceptor-mediated signaling events in a T cell line. Taken together, these results show that Clnk is a novel member of the SLP-76 family selectively expressed in cytokine-stimulated hemopoietic cells. Furthermore, they suggest that Clnk may be involved in a cross-talk mechanism between cytokine receptor and immunoreceptor signaling.
登录
查看更多内容
影响因子：
5.4
作者：
AMIGORENA, S;BONNEROT, C;TEILLAUD, JL
通讯作者：
TEILLAUD, JL
影响因子：
64.5
作者：
Pivniouk, V;Tsitsikov, E;Geha, RS
通讯作者：
Geha, RS
DOI：
10.1084/jem.189.8.1243
发表时间：
1999-04-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Law CL;Ewings MK;Chaudhary PM;Solow SA;Yun TJ;Marshall AJ;Hood L;Clark EA
通讯作者：
Clark EA
影响因子：
9.2
作者：
Liu, SK;Fang, N;McGlade, CJ
通讯作者：
McGlade, CJ
影响因子：
32.4
作者：
Fu, C;Turck, CW;Chan, AC
通讯作者：
Chan, AC