The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
复制标题
DOI：
10.1371/journal.pone.0050224
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Barr RG
中科院分区：
文献类型：
--
作者：
Harris B;Klein R;Jerosch-Herold M;Hoffman EA;Ahmed FS;Jacobs DR Jr;Klein BE;Wong TY;Lima JA;Cotch MF;Barr RG
Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45–84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV1) (P<0.001) and FEV1/forced vital capacity (FVC) ratio (P = 0.04). Albumin-to-creatinine ratio was inversely associated with FEV1 (P = 0.002) but not FEV1/FVC. Myocardial blood flow (n = 126) was associated with lower FEV1 (P = 0.02), lower FEV1/FVC (P = 0.001) and greater percentage LAA (P = 0.04). Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition.
登录
查看更多内容
影响因子：
3.3
作者：
COXSON, HO;MAYO, JR;HOGG, JC
通讯作者：
HOGG, JC
影响因子：
9.6
作者：
Hankinson, John L.;Kawut, Steven M.;Barr, R. Graham
通讯作者：
Barr, R. Graham
影响因子：
9.6
作者：
Chandra, Divay;Stamm, Jason A.;Sciurba, Frank C.
通讯作者：
Sciurba, Frank C.
DOI：
10.1164/rccm.201012-2061oc
发表时间：
2011-07-15
影响因子：
24.7
作者：
Gordon, Cynthia;Gudi, Kirana;Crystal, Ronald G.
通讯作者：
Crystal, Ronald G.
DOI：
10.1074/jbc.m804595200
发表时间：
2008-10-24
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Giordano RJ;Lahdenranta J;Zhen L;Chukwueke U;Petrache I;Langley RR;Fidler IJ;Pasqualini R;Tuder RM;Arap W
通讯作者：
Arap W