Method for Successfully Inducting Individuals Who Use Illicit Fentanyl Onto Buprenorphine/Naloxone.
Method for Successfully Inducting Individuals Who Use Illicit Fentanyl Onto Buprenorphine/Naloxone.
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DOI：
10.1111/ajad.13069
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Dunn KE
中科院分区：
文献类型：
--
作者：
Antoine D;Huhn AS;Strain EC;Turner G;Jardot J;Hammond AS;Dunn KE
使用典型的丁丙诺啡/纳洛酮诱导程序，暴露于芬太尼的个人面临着催促戒断的风险。这一系列病例描述了芬太尼检测呈阳性的四个人的丁丙诺啡/纳洛酮诱导。在完成常规丁丙诺啡/纳洛酮诱导策略的两名患者中，观察到丁丙诺啡沉淀戒断。又有两名患者完成了修订后的丁丙诺啡/纳洛酮诱导策略，该策略没有导致戒断。在已经处于轻/中度戒断状态的患者中使用多个2 mg剂量的丁丙诺啡/纳洛酮可以改善结果。使用非法芬太尼的人可能不太可能突然退出这项经修订的丁丙诺啡/纳洛酮诱导策略。
Individuals exposed to fentanyl are at risk of precipitated withdrawal using typical buprenorphine/naloxone induction procedures. This case series describes buprenorphine/naloxone inductions of four individuals who tested positive for fentanyl. Buprenorphine-precipitated withdrawal was observed in two individuals who completed a conventional buprenorphine/naloxone induction strategy. Two more individuals completed a revised buprenorphine/naloxone induction strategy that did not precipitate withdrawal. Using multiple 2mg doses of buprenorphine/naloxone in patients already in mild/moderate withdrawal improved outcomes. Persons who use illicit fentanyl might be less likely to experience precipitated withdrawal from this revised buprenorphine/naloxone induction strategy.
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