Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors.
Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors.
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DOI：
10.1038/s41467-021-26903-7
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发表时间：
2021-11-16
影响因子：
16.6
通讯作者：
Thompson WK
中科院分区：
文献类型：
--
作者：
Krebs MD;Themudo GE;Benros ME;Mors O;Børglum AD;Hougaard D;Mortensen PB;Nordentoft M;Gandal MJ;Fan CC;Geschwind DH;Schork AJ;Werge T;Thompson WK
精神分裂症是一种异质性疾病，表现出多样性的表现和结果，复杂的治疗和恢复。为了探索这种异质性，我们利用全面的丹麦健康登记处进行了一项前瞻性的纵向研究，从出生的5432人谁最终被诊断为精神分裂症，建立个人轨迹，代表序列的共病诊断，并描述模式的个人水平的变异性。我们发现精神共病在精神分裂症患者中普遍存在（82%），多发病率在特定的时间顺序对中更常见。三个潜在因素捕获了79%的纵向共病变异，并与共病诊断的数量、儿童与成人共病的存在和药物滥用广泛相关。因素得分的聚类显示了五个稳定的个体聚类，与特定的风险因素和结果相关。精神分裂症的临床表现和病程可能与包括精神障碍家族史在内的病因学因素的异质性有关。精神分裂症是一种复杂的疾病，其中个体经历不同的症状和结果，这些症状和结果可以通过其他诊断中的模式来捕获。在这里，作者使用计算方法来总结这些模式，并提出它们与遗传和环境暴露有关。
Schizophrenia is a heterogeneous disorder, exhibiting variability in presentation and outcomes that complicate treatment and recovery. To explore this heterogeneity, we leverage the comprehensive Danish health registries to conduct a prospective, longitudinal study from birth of 5432 individuals who would ultimately be diagnosed with schizophrenia, building individual trajectories that represent sequences of comorbid diagnoses, and describing patterns in the individual-level variability. We show that psychiatric comorbidity is prevalent among individuals with schizophrenia (82%) and multi-morbidity occur more frequently in specific, time-ordered pairs. Three latent factors capture 79% of variation in longitudinal comorbidity and broadly relate to the number of co-occurring diagnoses, the presence of child versus adult comorbidities and substance abuse. Clustering of the factor scores revealed five stable clusters of individuals, associated with specific risk factors and outcomes. The presentation and course of schizophrenia may be associated with heterogeneity in etiological factors including family history of mental disorders. Schizophrenia is a complex disorder where individuals experience different symptoms and outcomes that can be captured by patterns in other diagnoses. Here the authors use computational approaches to summarize these patterns and suggest they are associated with genetic and environmental exposure.
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影响因子：
4.5
作者：
Dixon, L
通讯作者：
Dixon, L
DOI：
10.1186/1745-0179-5-4
发表时间：
2009-02-12
期刊：
Clinical practice and epidemiology in mental health : CP & EMH
影响因子：
--
作者：
Bock, Camilla;Bukh, Jens Drachmann;Kessing, Lars Vedel
通讯作者：
Kessing, Lars Vedel
DOI：
10.1146/annurev-clinpsy-032813-153645
发表时间：
2014-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 10
影响因子：
--
作者：
Fusar-Poli, P.;Carpenter, W. T.;McGlashan, T. H.
通讯作者：
McGlashan, T. H.
影响因子：
25.8
作者：
Greenwood, Tiffany A.;Lazzeroni, Laura C.;Braff, David L.
通讯作者：
Braff, David L.
影响因子：
6.3
作者：
Abbott, A;Tsay, A
通讯作者：
Tsay, A