Immunomodulating functions of human leukocyte antigen-G and its role in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Immunomodulating functions of human leukocyte antigen-G and its role in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
复制标题
人白细胞抗原-G的免疫调节功能及其在异基因造血干细胞移植后移植物抗宿主病中的作用
DOI：
10.1007/s00277-021-04486-z
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发表时间：
2021-06
影响因子：
3.5
通讯作者：
Ping B
中科院分区：
文献类型：
--
作者：
Bu X;Zhong J;Li W;Cai S;Gao Y;Ping B
异基因造血干细胞移植（allo-HSCT）是一种治疗多种血液系统恶性肿瘤和非血液系统恶性肿瘤的潜在治疗策略。然而，移植物抗宿主病（GVHD）是一种常见的严重的移植相关并发症，它极大地限制了allo-HSCT的疗效，也是异基因HCT受者发病率和死亡率的重要原因。有效预防GVHD主要依赖于诱导外周免疫耐受。人类白细胞抗原G（human leukocyte antigen-G，HLA-G）是一种非经典的MHC I类分子，具有很强的免疫抑制作用，在免疫耐受中起着重要作用。HLA-G根据免疫细胞和系统的激活状态触发不同的反应。它还通过诱导调节细胞发挥长期免疫耐受机制。在这篇综述中，我们证明了人类白细胞抗原-G的免疫调节特性，并强调HLA-G作为GVHD的免疫调节剂的作用。此外，HLA-G还可以作为GVHD的良好预测因子，并为GVHD的治疗提供了新的靶点。
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapeutic strategy to treat several hematological malignancies and non-hematological malignancies. However, graft-versus-host disease (GVHD) is a frequent and serious transplant-related complication which dramatically restrains the curative effect of allo-HSCT and a significant cause of morbidity and mortality in allogeneic HCT recipients. Effective prevention of GVHD mainly depends on the induction of peripheral immune tolerance. Human leukocyte antigen-G (HLA-G) is a non-classical MHC class I molecule with a strong immunosuppressive function, which plays a prominent role in immune tolerance. HLA-G triggers different reactions depending on the activation state of the immune cells and system. It also exerts a long-term immune tolerance mechanism by inducing regulatory cells. In this present review, we demonstrate the immunomodulatory properties of human leukocyte antigen-G and highlight the role of HLA-G as an immune regulator of GVHD. Furthermore, HLA-G could also serve as a good predictor of GVHD and represent a new therapeutic target for GVHD.
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影响因子：
4.8
作者：
Kordelas, Lambros;Nardi, Fabiola da Silva;Rebmann, Vera
通讯作者：
Rebmann, Vera
影响因子：
6.5
作者：
La Nasa, Giorgio;Littera, Roberto;Carcassi, Carlo
通讯作者：
Carcassi, Carlo
影响因子：
10.1
作者：
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通讯作者：
Gregori, Silvia
DOI：
10.1038/nri3212
发表时间：
2012-05-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.4
作者：
Biedron, Monika;Rybka, Justyna;Kuliczkowski, Kazimierz
通讯作者：
Kuliczkowski, Kazimierz