Changes in preterm birth during the COVID-19 pandemic by duration of exposure and race and ethnicity.

Changes in preterm birth during the COVID-19 pandemic by duration of exposure and race and ethnicity.
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DOI:
10.1038/s41372-022-01488-1
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发表时间:
2022-10
影响因子:
2.9
通讯作者:
Burris, Heather H.
Burris, Heather H.
中科院分区:
医学3区
文献类型:
--
作者:
Mullin, Anne M.;Handley, Sara C.;Lundsberg, Lisbet;Elovitz, Michal A.;Lorch, Scott A.;McComb, Elias J.;Montoya-Williams, Diana;Yang, Nancy;Dysart, Kevin;Son, Moeun;Greenspan, Jay;Culhane, Jennifer F.;Burris, Heather H.

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我们的目的是确定冠状病毒病-2019 (COVID-19)大流行暴露时间是否与PTB相关,以及大流行是否改变了种族差异。我们分析了费城的出生情况,并在纽黑文进行了复制。与前两年的匹配月份相比,我们分析了总体PTB,特定PTB表型和死产。总的来说,除了以下例外,不同时期的肺结核相似。与大流行前相比,妊娠早期(<14周)大流行暴露与< 28周(aRR 0.60[0.30-1.10])的PTB风险较低相关(aRR 1.77[0.78-3.97])(相互作用p = 0.04)。在大流行期间,白人患者中< 32周的PTB减少,导致黑白差异从2.51 aRR (95%CI: 1.53-4.16)无显著扩大到4.07 aRR (95%CI: 1.56-12.01)(相互作用P = 0.41)。纽黑文没有重复的研究结果。我们没有发现PTB的整体大流行效应,但对一些患者的潜在间接益处可能会扩大差异。
We aimed to determine whether coronavirus-disease-2019 (COVID-19) pandemic exposure duration was associated with PTB and if the pandemic modified racial disparities. We analyzed Philadelphia births and replicated in New Haven. Compared to matched months in two prior years, we analyzed overall PTB, specific PTB phenotypes, and stillbirth. Overall, PTB was similar between periods with the following exceptions. Compared to pre-pandemic, early pregnancy (<14 weeks’) pandemic exposure was associated with lower risk of PTB < 28 weeks’ (aRR 0.60 [0.30–1.10]) and later exposure with higher risk (aRR 1.77 [0.78–3.97]) (interaction p = 0.04). PTB < 32 weeks’ among White patients decreased during the pandemic, resulting in non-significant widening of the Black-White disparity from aRR 2.51 (95%CI: 1.53–4.16) to aRR 4.07 (95%CI: 1.56–12.01) (interaction P = 0.41). No findings replicated in New Haven. We detected no overall pandemic effects on PTB, but potential indirect benefits for some patients which could widen disparities remains possible.
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