Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats.
Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats.
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DOI：
10.3164/jcbn.10-78
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发表时间：
2011-05
影响因子：
2.4
通讯作者：
Higashino H
中科院分区：
文献类型：
--
作者：
Niwa A;Tajiri T;Higashino H
已知甘薯、巴西蘑菇和雪莲花对糖尿病有良好的影响。为了阐明其抗糖尿病疗效和降血糖机制，我们对链脲佐菌素诱导的糖尿病大鼠每日口服甘薯粉（5 g kg−1 d−1）、巴西蘑菇（1 g kg−1 d−1）或雪莲花（4 g kg−1 d−1），持续2个月。用甘薯或巴西蘑菇治疗，但不是雪莲花，显著抑制了空腹血糖和血红蛋白A1 c水平的增加，并恢复了糖尿病期间的体重减轻。口服葡萄糖给药试验后，血清胰岛素水平随着甘薯或巴西蘑菇的治疗而沿着升高。此外，甘薯和巴西蘑菇降低了糖尿病大鼠白细胞和血管匀浆、血清8-氧代-2 '-脱氧鸟苷和血管硝基酪氨酸形成的超氧化物的产生，达到正常对照动物的水平。甘薯可显著抑制糖尿病大鼠应激和炎症相关的p38丝裂原活化蛋白激酶活性和肿瘤坏死因子-α的产生。组织学检查也显示用甘薯或巴西蘑菇处理后胰腺β-细胞质量的改善。这些结果表明，甘薯或巴西蘑菇的降血糖作用是由于它们抑制氧化应激和促炎细胞因子的产生，然后改善胰腺β细胞质量。
Ipomoea batatas, Agaricus blazei and Smallanthus sonchifolius are known to favorably influence diabetes mellitus. To clarify their antidiabetic efficacy and hypoglycemic mechanisms, we treated streptozotocin-induced diabetic rats with daily oral feeding of powdered Ipomoea batatas (5 g kg−1 d−1), Agaricus blazei (1 g kg−1 d−1) or Smallanthus sonchifolius (4 g kg−1 d−1) for 2 months. Treatments with Ipomoea batatas or Agaricus blazei, but not Smallanthus sonchifolius, significantly suppressed the increases of fasting plasma glucose and hemoglobin A1c levels, and restored body weight loss during diabetes. Serum insulin levels after oral glucose administration tests increased along the treatments of Ipomoea batatas or Agaricus blazei. Moreover, Ipomoea batatas and Agaricus blazei reduced superoxide production from leukocytes and vascular homogenates, serum 8-oxo-2'-deoxyguanosine, and vascular nitrotyrosine formation of diabetic rats to comparable levels of normal control animals. Stress- and inflammation-related p38 mitogen-activated protein kinase activity and tumor necrosis factor-α production of diabetic rats were significantly depressed by Ipomoea batatas administration. Histological examination also exhibited improvement of pancreatic β-cells mass after treatments with Ipomoea batatas or Agaricus blazei. These results suggest that hypoglycemic effects of Ipomoea batatas or Agaricus blazei result from their suppression of oxidative stress and proinflammatory cytokine production followed by improvement of pancreatic β-cells mass.
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影响因子：
5
作者：
Lakey, JRT;Suarez-Pinzon, WL;Rabinovitch, A
通讯作者：
Rabinovitch, A
DOI：
10.1615/intjmedmushr.v8.i4.40
发表时间：
2006-01-01
影响因子：
1.2
作者：
Hashimoto, Satoshi;Akanuma, Akiko M.;Ohno, Naohito
通讯作者：
Ohno, Naohito
影响因子：
9.8
作者：
Ludvik, B;Waldhäusl, W;Pacini, G
通讯作者：
Pacini, G
影响因子：
3.1
作者：
KAWAGISHI, H;INAGAKI, R;NAKAMURA, T
通讯作者：
NAKAMURA, T
DOI：
10.1073/pnas.93.21.11853
发表时间：
1996-10-15
影响因子：
11.1
作者：
MacMillanCrow, LA;Crow, JP;Thompson, JA
通讯作者：
Thompson, JA