RECK expression is associated with angiogenesis and immunogenic Tumor Microenvironment in Hepatocellular Carcinoma, and is a prognostic factor for better survival.
RECK expression is associated with angiogenesis and immunogenic Tumor Microenvironment in Hepatocellular Carcinoma, and is a prognostic factor for better survival.
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RECK 表达与肝细胞癌中的血管生成和免疫原性肿瘤微环境相关，并且是更好生存的预后因素
DOI：
10.7150/jca.56167
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发表时间：
2021
影响因子：
3.9
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Dong ZR;Chen ZQ;Yang XY;Ding ZN;Liu KX;Yan LJ;Meng GX;Yang YF;Yan YC;Yao SY;Yang CC;Zhi XT;Li T
血管生成和免疫抑制被描述为密切相关的过程，可以并行发生。作为基质金属蛋白酶的抑制剂，逆转诱导富含半胱氨酸蛋白与Kazal基序（RECK）在肝细胞癌（HCC）中的水平是否反映了血管生成和免疫抑制之间的联系仍然是未知的。我们从癌症基因组图谱数据库中分析了肝癌的RNA表达、免疫浸润和生存率。基于ESTIMATE算法计算免疫评分和基质评分，以量化HCC中的免疫和基质成分。通过组织芯片免疫组化进一步研究RECK与临床病理特征的关系。我们发现RECK高表达患者的预后明显好于RECK低表达患者。高RECK表达与高ESTIMATE评分、募集更多肿瘤浸润淋巴细胞、低肿瘤纯度和高PD-L1表达相关。此外，RECK阳性表达与较低的血管浸润和复发率、较低的甲胎蛋白（AFP）水平和微血管密度以及较好的肿瘤分化相关。多因素分析显示RECK表达降低是复发和预后不良的独立预后因素。总之，RECK高表达反映了HCC的免疫原性和低血管状态。RECK是一个很有前途的预后指标，肝癌的生存，并可能作为一个补充指标，为患者接受抗血管生成治疗或免疫治疗。
Angiogenesis and immunosuppression have been described as closely related processes that can occur in parallel. As an inhibitor of matrix metalloproteinase, whether the level of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) in hepatocellular carcinoma (HCC) reflects a link between angiogenesis and immunosuppression is still unknown. We analyzed RNA expression, immune infiltration and survival of HCC from The Cancer Genome Atlas databases. Immune scores and stromal scores were calculated based on the ESTIMATE algorithm to quantify the immune and stromal components in HCC. The association between RECK and clinicopathological features was further investigated by immunohistochemistry on tissue microarray. We found that the prognosis of patients with high RECK expression was significantly better than that of patients with low RECK expression. High RECK expression was associated with high ESTIMATE Score, recruitment of more tumor-infiltrating lymphocytes, low tumor purity, and high PD-L1 expression. In addition, positive RECK expression was associated with a lower incidence of vascular invasion and recurrence, a lower level of alpha fetoprotein (AFP) and microvessel density and a better tumor differentiation. Multivariate analyses revealed that reduced RECK expression was an independent prognostic factor for recurrence and poor prognosis. In conclusion, high RECK expression reflects an immunogenic and hypovascularity status in HCC. RECK is a promising prognostic marker for survival of HCC and may act as a complementary indicator for patients to receive anti-angiogenic therapy or immunotherapy.
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DOI：
10.1111/liv.13697
发表时间：
2018-08
期刊：
Liver international : official journal of the International Association for the Study of the Liver
影响因子：
--
作者：
Chang B;Shen L;Wang K;Jin J;Huang T;Chen Q;Li W;Wu P
通讯作者：
Wu P
影响因子：
10.9
作者：
Brown ZJ;Heinrich B;Steinberg SM;Yu SJ;Greten TF
通讯作者：
Greten TF
影响因子：
6.2
作者：
Clark, Jonathan C. M.;Akiyama, Toru;Choong, Peter F. M.
通讯作者：
Choong, Peter F. M.
影响因子：
4.6
作者：
Ruiz-Gomez, Gloria;Vogel, Sarah;Hempel, Ute
通讯作者：
Hempel, Ute
影响因子：
13.5
作者：
Calderaro, Julien;Rousseau, Benoit;Pawlotsky, Jean-Michel
通讯作者：
Pawlotsky, Jean-Michel